{"id":"W2127940865","doi":"10.4049/jimmunol.1200391","title":"Graft-versus-Host Disease Impairs Vaccine Responses through Decreased CD4+ and CD8+ T Cell Proliferation and Increased Perforin-Mediated CD8+ T Cell Apoptosis","year":2012,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Cancer Institute; National Institutes of Health","keywords":"CD8; Perforin; Cytotoxic T cell; Immunology; Graft-versus-host disease; T cell; Apoptosis; Biology; Adoptive cell transfer; Cancer research; Immune system; Stem cell; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001539954,0.0004847271,0.0003751297,0.0001866852,0.00006289052,0.0003059632,0.0001589254,0.0003452491,0.001177255],"category_scores_gemma":[0.0001472438,0.0001534007,0.0001800883,0.0001082125,0.0002172621,0.0003208132,0.0001535576,0.001087879,0.0002913773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000147619,"about_ca_system_score_gemma":0.0001679537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008991105,"about_ca_topic_score_gemma":0.000128756,"domain_scores_codex":[0.999777,0.00004418028,0.00002795025,0.0000495177,0.00004109122,0.00006020861],"domain_scores_gemma":[0.9998485,0.00002420191,0.00005658276,0.00001388239,0.000009143063,0.00004759528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003290241,0.0001133194,0.0003330121,0.00005545709,0.000005289651,0.00003729987,0.00001160239,0.00006458708,0.9967905,0.00005430423,0.00002581214,0.002179752],"study_design_scores_gemma":[0.00007834985,0.0032604,0.007943689,0.00001363839,0.00004397687,0.0006903285,0.00003253005,0.000931203,0.9852002,0.0001298494,0.001670896,0.000004930488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970863,0.001264269,0.0009114435,0.00005690742,0.00002403441,0.00001824437,0.0001075751,0.0000649892,0.0004663203],"genre_scores_gemma":[0.9967487,0.0007600358,0.0009328775,0.00007541294,0.00001691623,0.00003084551,0.0001816695,0.00001387847,0.001239651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177255,"threshold_uncertainty_score":0.003938317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116693779225995,"score_gpt":0.238418198567214,"score_spread":0.2267488206446145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}