{"id":"W2128005557","doi":"10.2337/db13-0816","title":"High-Fat Diet–Induced Mitochondrial Biogenesis Is Regulated by Mitochondrial-Derived Reactive Oxygen Species Activation of CaMKII","year":2014,"lang":"en","type":"article","venue":"Diabetes","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; University of Guelph","funders":"","keywords":"Ryanodine receptor; SERCA; Mitochondrial ROS; Mitochondrial biogenesis; Mitochondrion; Reactive oxygen species; Calcium; Cell biology; Chemistry; Internal medicine; Endocrinology; Biology; Endoplasmic reticulum; Biochemistry; ATPase; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0000857334,0.0003199723,0.0008026149,0.0001902149,0.0001069887,0.00002103311,0.0001546094,0.0002876847,0.000336678],"category_scores_gemma":[0.0004575144,0.0002800535,0.0001934123,0.0003604035,0.0001235722,0.0001926378,0.00005177893,0.0001533864,0.00006454778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004775528,"about_ca_system_score_gemma":0.00004929518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00026065,"about_ca_topic_score_gemma":0.000002981387,"domain_scores_codex":[0.9980987,0.0001174591,0.0004687597,0.0004799643,0.0004160829,0.0004189769],"domain_scores_gemma":[0.9984137,0.0001992521,0.000331757,0.0005668736,0.0003021584,0.0001862292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003749369,0.0001532684,0.0006766575,0.00005147521,0.0003310985,7.225051e-7,0.0006289038,6.157638e-7,0.972485,0.0001765265,0.02220467,0.002916097],"study_design_scores_gemma":[0.002414532,0.0004544495,0.02054755,0.0001163566,0.0003658349,4.692026e-7,0.0001015987,0.0000294232,0.942839,0.0002136388,0.03265663,0.0002605564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99574,0.00027709,0.00008049082,0.001423847,0.0009858403,0.0006526107,0.00009423398,0.00009895509,0.0006469093],"genre_scores_gemma":[0.9926876,0.00004544497,0.001470246,0.0004257486,0.001572148,0.00005144786,0.0004839662,0.00006540778,0.003197924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02964607,"threshold_uncertainty_score":0.9999652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428988321511364,"score_gpt":0.2351551981870409,"score_spread":0.2208653149719273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}