{"id":"W2128019032","doi":"10.1158/0008-5472.can-04-0012","title":"Excellent <b> <i>In vivo</i> </b> Bystander Activity of Fludarabine Phosphate against Human Glioma Xenografts that Express the <b> <i>Escherichia coli</i> </b> Purine Nucleoside Phosphorylase Gene","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Bystander effect; Purine nucleoside phosphorylase; Fludarabine; In vivo; Nucleoside analogue; Cancer research; Cytotoxic T cell; Glioma; Escherichia coli; Prodrug; Chemistry; Pharmacology; Biology; Nucleoside; Purine; Immunology; In vitro; Biochemistry; Chemotherapy; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002158539,0.0004030594,0.0002251661,0.0001589862,0.00009345929,0.0002473979,0.0001146187,0.0003088768,0.000730257],"category_scores_gemma":[0.0001285133,0.0000921225,0.0001435301,0.00008152197,0.0001547312,0.0001648602,0.0001122114,0.000497794,0.0001939726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000175064,"about_ca_system_score_gemma":0.0001605054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00070878,"about_ca_topic_score_gemma":0.0006006437,"domain_scores_codex":[0.9998317,0.00003987297,0.00001412281,0.0000293078,0.00004664874,0.000038474],"domain_scores_gemma":[0.9998766,0.00003458395,0.00003003141,0.00001754562,0.00001584326,0.0000253761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006164668,0.00003277048,0.00007755533,0.00001166168,0.000003198604,0.000008737866,0.000006660832,0.000065564,0.9990227,0.00004222623,0.00001909612,0.000648183],"study_design_scores_gemma":[0.0000083656,0.0005648005,0.00115631,0.000001568385,0.000005841244,0.00007656588,0.000006163443,0.0003155255,0.9973627,0.00001155921,0.0004890223,0.000001654705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929209,0.0008296876,0.00417767,0.00005047459,0.000009984105,0.0000466811,0.0002185942,0.0001141269,0.001631962],"genre_scores_gemma":[0.9963044,0.0002738266,0.002032029,0.00002498466,0.000003952529,0.00003194544,0.0003348868,0.00002357307,0.0009704749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000730257,"threshold_uncertainty_score":0.002442896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04076909253490917,"score_gpt":0.3429121560609821,"score_spread":0.302143063526073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}