{"id":"W2128019032","doi":"10.1158/0008-5472.can-04-0012","title":"Excellent <b> <i>In vivo</i> </b> Bystander Activity of Fludarabine Phosphate against Human Glioma Xenografts that Express the <b> <i>Escherichia coli</i> </b> Purine Nucleoside Phosphorylase Gene","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Bystander effect; Purine nucleoside phosphorylase; Fludarabine; In vivo; Nucleoside analogue; Cancer research; Cytotoxic T cell; Glioma; Escherichia coli; Prodrug; Chemistry; Pharmacology; Biology; Nucleoside; Purine; Immunology; In vitro; Biochemistry; Chemotherapy; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001693928,0.0003736495,0.0004122972,0.0002020122,0.0004037709,0.00008192222,0.001153307,0.0002388604,0.0003031807],"category_scores_gemma":[0.00006906653,0.0003083815,0.0002007561,0.0008643225,0.0008425621,0.00002174849,0.0005786283,0.0007193783,0.00001686943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000306195,"about_ca_system_score_gemma":0.0007690194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001696358,"about_ca_topic_score_gemma":0.002371705,"domain_scores_codex":[0.9957975,0.0005031709,0.000407389,0.0008655221,0.001224119,0.001202353],"domain_scores_gemma":[0.9977355,0.00006148334,0.0001416666,0.001315558,0.0004021868,0.0003436073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004060406,0.0004939529,0.0004276886,0.00007916937,0.0000891396,0.00006279589,0.0002021026,0.00132981,0.9895817,0.00002642193,0.002410373,0.001236443],"study_design_scores_gemma":[0.003364728,0.001303066,0.0004284261,0.00009257884,0.000008182032,0.00000242038,0.0001314762,0.00001351208,0.9785247,0.0001005814,0.01571424,0.0003161166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893354,0.007670798,0.00006494673,0.0007238315,0.00014267,0.001223371,0.0001285365,0.00002335141,0.0006870636],"genre_scores_gemma":[0.9920023,0.006039015,0.00005447623,0.0002505372,0.0002805632,0.0005968865,0.00002735518,0.0001100993,0.0006387376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01330387,"threshold_uncertainty_score":0.9999368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04076909253490917,"score_gpt":0.3429121560609821,"score_spread":0.302143063526073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}