{"id":"W2128029881","doi":"10.1158/1055-9965.epi-14-0532","title":"Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers","year":2014,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Lunenfeld-Tanenbaum Research Institute; Centre hospitalier universitaire de Québec","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; Fundación Mutua Madrileña; Canadian Institutes of Health Research; National Center for Research Resources; Institut Català de la Salut; Deutsche Krebshilfe; Instituto de Salud Carlos III; Lunds Universitet; Sahlgrenska Universitetssjukhuset; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Cancer Association of South Africa; Generalitat de Catalunya; National Institute for Health and Care Research; Cancer Research UK; Francis Crick Institute; Deutsches Krebsforschungszentrum; Helsingin ja Uudenmaan Sairaanhoitopiiri; McGill University; Royal Marsden NHS Foundation Trust; Breast Cancer Research Foundation; Uppsala Universitet; Lietuvos Mokslo Taryba; National Institutes of Health; Ovarian Cancer Research Fund; Génome Québec","keywords":"Ovarian cancer; Breast cancer; Mutation; Oncology; Medicine; Genetics; Cancer; Internal medicine; Cancer research; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009783282,0.0003192724,0.0002557035,0.001086811,0.0002865794,0.0004697248,0.0003258226,0.0004299527,0.002393427],"category_scores_gemma":[0.002646809,0.0002005166,0.0005373455,0.0009453394,0.0003153951,0.0002018148,0.0002613607,0.0003528938,0.0001650632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001754653,"about_ca_system_score_gemma":0.0002542851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001907265,"about_ca_topic_score_gemma":0.001917845,"domain_scores_codex":[0.999616,0.0001077462,0.00004280532,0.0001228025,0.00005987211,0.00005084213],"domain_scores_gemma":[0.9985518,0.0006640528,0.0005221772,0.0001034496,0.0000573822,0.0001011619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005830051,0.00002567999,0.9932737,0.00001758025,0.0001549426,0.0001856311,0.00004904612,0.000129125,0.002994772,0.00007253443,0.00006157684,0.002452395],"study_design_scores_gemma":[0.00003264227,0.0001535522,0.9964834,0.00001115243,0.000333749,0.0006924541,0.0000532893,0.0004028052,0.001414829,0.0001692846,0.0002480577,0.000004631671],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987565,0.0004241708,0.0003133044,0.00003531936,0.000005205022,0.000006386553,0.0002124941,0.000007365108,0.0002391363],"genre_scores_gemma":[0.9992139,0.0001157146,0.0003922106,0.00001572145,0.000007288083,0.000005584366,0.000159557,0.000003558953,0.0000865121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002393427,"threshold_uncertainty_score":0.008006811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01515064617218013,"score_gpt":0.31227075291423,"score_spread":0.2971201067420498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}