{"id":"W2128052459","doi":"10.1016/s0022-2836(03)00360-7","title":"Transforming Growth Factor-beta (TGF-β) Binding to the Extracellular Domain of the Type II TGF-β Receptor: Receptor Capture on a Biosensor Surface Using a New Coiled-coil Capture System Demonstrates that Avidity Contributes Significantly to High Affinity Binding","year":2003,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Avidity; Receptor; Chemistry; Biophysics; Ligand (biochemistry); Biosensor; Surface plasmon resonance; Extracellular; Receptor–ligand kinetics; Transforming growth factor beta; Cell surface receptor; Dissociation constant; Gene isoform; Biochemistry; Biology; Materials science; Antibody; Nanotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003473862,0.0004470087,0.0003347069,0.0001779357,0.0001778355,0.000409117,0.0007124036,0.0006983721,0.001049876],"category_scores_gemma":[0.0002687013,0.0002525354,0.000302909,0.0001022758,0.00027275,0.0003004571,0.0003268412,0.0006741342,0.0006493008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003420507,"about_ca_system_score_gemma":0.0001386476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003691616,"about_ca_topic_score_gemma":0.0006188154,"domain_scores_codex":[0.9997109,0.00005500262,0.00001558867,0.00007315113,0.00007565358,0.00006966099],"domain_scores_gemma":[0.999805,0.00007227599,0.00002634179,0.00002439984,0.00003132129,0.00004058057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003719272,0.0000133998,0.00004180434,0.0000108367,0.000003491796,0.00002022791,0.000008958557,0.00002493579,0.9990941,0.00008576737,0.00003540932,0.0006239286],"study_design_scores_gemma":[0.00001474081,0.0001451704,0.000631288,0.000002589942,0.00000912198,0.0002166764,0.000007212372,0.001809626,0.9962367,0.00003336478,0.0008860191,0.000007442836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9571502,0.001407041,0.03861378,0.000419262,0.00009693714,0.00005718179,0.00008843221,0.0002035731,0.001963565],"genre_scores_gemma":[0.9792828,0.0006789431,0.01568246,0.0003404079,0.00004888334,0.00004824445,0.0003173893,0.00003852278,0.003562347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049876,"threshold_uncertainty_score":0.003512204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01837214936641642,"score_gpt":0.25054378624682,"score_spread":0.2321716368804036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}