{"id":"W2128054910","doi":"10.1038/gt.2008.94","title":"Syncytia formation affects the yield and cytotoxicity of an adenovirus expressing a fusogenic glycoprotein at a late stage of replication","year":2008,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Oncolytics Biotech; Generalitat de Catalunya; European Commission","keywords":"Biology; Virology; Syncytium; Cytotoxicity; Multiplicity of infection; Virus; Glycoprotein; Viral replication; Molecular biology; Adenoviridae; Viral envelope; Gene; Genetic enhancement; In vitro; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006059533,0.0006376356,0.0003918555,0.0005208724,0.0002451445,0.0004630295,0.0002834631,0.0005618329,0.001204648],"category_scores_gemma":[0.0006723032,0.0002899659,0.0004190367,0.0003084616,0.0003720511,0.0004790764,0.0003486583,0.0007648942,0.0004208465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006008588,"about_ca_system_score_gemma":0.0003167943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008345426,"about_ca_topic_score_gemma":0.0005249027,"domain_scores_codex":[0.9995064,0.0001224789,0.00006903037,0.00006852343,0.0001236285,0.0001099207],"domain_scores_gemma":[0.999056,0.0004412966,0.0001766575,0.0001016581,0.0001093904,0.0001150389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001054931,0.00001490112,0.0000871835,0.000008668569,0.000003243622,0.00003343908,0.00001115501,0.00005571311,0.9993734,0.00009590186,0.000008118909,0.0002029015],"study_design_scores_gemma":[0.000004433399,0.0001389146,0.0006387666,0.000001064237,0.000006082306,0.00005868118,0.000007053822,0.0002912836,0.9986272,0.00001758615,0.0002071873,0.000001815476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931495,0.001020967,0.003791955,0.00005143367,0.00003023275,0.00002612265,0.0002457807,0.00007484519,0.001609228],"genre_scores_gemma":[0.9963661,0.0003511313,0.001084035,0.00002088827,0.000006099402,0.00001616124,0.0004250352,0.00003296702,0.001697528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001204648,"threshold_uncertainty_score":0.004359543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03572539537729032,"score_gpt":0.2943277485047488,"score_spread":0.2586023531274585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}