{"id":"W2128054910","doi":"10.1038/gt.2008.94","title":"Syncytia formation affects the yield and cytotoxicity of an adenovirus expressing a fusogenic glycoprotein at a late stage of replication","year":2008,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Oncolytics Biotech; Generalitat de Catalunya; European Commission","keywords":"Biology; Virology; Syncytium; Cytotoxicity; Multiplicity of infection; Virus; Glycoprotein; Viral replication; Molecular biology; Adenoviridae; Viral envelope; Gene; Genetic enhancement; In vitro; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004437361,0.0001272952,0.0001511967,0.00004655602,0.0001531736,0.000008016787,0.0002189822,0.0001065159,0.00002835433],"category_scores_gemma":[0.00003035116,0.00009855508,0.00006277135,0.0001086273,0.0001644419,0.00001315626,0.000072521,0.00006935227,0.000001301996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001874726,"about_ca_system_score_gemma":0.00006325647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004417776,"about_ca_topic_score_gemma":0.00008744255,"domain_scores_codex":[0.9989713,0.0001539984,0.0002096675,0.0002805916,0.0002005613,0.000183817],"domain_scores_gemma":[0.9988438,0.00002164516,0.0001919875,0.0008143259,0.00007668834,0.00005152036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002914291,0.00005786525,0.0002271222,0.00002140687,0.00004158253,0.000001191706,0.0003670715,0.0001390047,0.9890882,0.000001872922,0.00002357515,0.007116858],"study_design_scores_gemma":[0.0007637098,0.002114449,0.002432709,0.00001063664,0.000003785429,0.00001837904,0.00002420712,0.0002912155,0.9940324,0.00001727986,0.0001900754,0.0001010961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954152,0.003463493,0.0003846243,0.00005225404,0.0000117511,0.000587068,0.00003376881,0.0000101398,0.00004174046],"genre_scores_gemma":[0.9968824,0.00240606,0.0002234239,0.0001017681,0.00004791051,0.0000568718,0.00004150216,0.00002192853,0.0002181697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007015762,"threshold_uncertainty_score":0.4018959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03572539537729032,"score_gpt":0.2943277485047488,"score_spread":0.2586023531274585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}