{"id":"W2128059069","doi":"10.1210/en.2003-1768","title":"Transgenic Mice Expressing Fibroblast Growth Factor 23 under the Control of the α1(I) Collagen Promoter Exhibit Growth Retardation, Osteomalacia, and Disturbed Phosphate Homeostasis","year":2004,"lang":"en","type":"article","venue":"Endocrinology","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":501,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"Karolinska Institutet","keywords":"Internal medicine; Endocrinology; Fibroblast growth factor 23; Hypophosphatemia; Osteomalacia; Genetically modified mouse; PHEX; Rickets; Transgene; Fibroblast growth factor; Homeostasis; Biology; Chemistry; Parathyroid hormone; Vitamin D and neurology; Calcium; Medicine; Biochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000429236,0.0002243669,0.0003640441,0.00005267759,0.0002178559,0.00002001873,0.0001490935,0.00007791928,0.00003191875],"category_scores_gemma":[0.00004775423,0.0001276284,0.0001285336,0.0001762516,0.000331207,0.00008771471,0.0000503801,0.0001260339,0.00001165324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000586425,"about_ca_system_score_gemma":0.0000934494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001712688,"about_ca_topic_score_gemma":0.00007394469,"domain_scores_codex":[0.9986801,0.0001101413,0.0003015973,0.0003163223,0.0001825457,0.0004093072],"domain_scores_gemma":[0.999298,0.00007944827,0.0001482463,0.0003037437,0.00009952766,0.00007100484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00446532,0.00281848,0.4527835,0.0004455383,0.005267448,0.0002349211,0.01785931,0.0001525028,0.4930811,0.0152627,0.002586979,0.005042156],"study_design_scores_gemma":[0.01578857,0.0006457224,0.6762035,0.00008385207,0.0005476366,0.0002164483,0.000749488,0.00002004523,0.3026483,0.002491264,0.0003352475,0.0002699255],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879325,0.003882168,0.0005799654,0.006071197,0.0001063278,0.0009165597,0.00009604142,0.0000326001,0.0003826589],"genre_scores_gemma":[0.9988564,0.0002476445,0.0001004054,0.0004337996,0.0000432095,0.00005556327,0.00002315103,0.00002456218,0.0002152989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.22342,"threshold_uncertainty_score":0.5204534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286182065581101,"score_gpt":0.242002131714082,"score_spread":0.229140311058271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}