{"id":"W2128084065","doi":"10.1523/jneurosci.2730-05.2006","title":"Single Transmembrane Domain Insulin-Like Growth Factor-II/Mannose-6-Phosphate Receptor Regulates Central Cholinergic Function by Activating a G-Protein-Sensitive, Protein Kinase C-Dependent Pathway","year":2006,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McGill University","funders":"Alzheimer Society; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Fondation pour la Recherche Médicale; Natural Sciences and Engineering Research Council of Canada","keywords":"Cell biology; Biology; Protein kinase C; Signal transduction; Biochemistry; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004434894,0.0003410132,0.0001482006,0.0001121539,0.0000725706,0.0001570394,0.0001360685,0.0001643418,0.0006344522],"category_scores_gemma":[0.00006128928,0.00006268688,0.0001908681,0.00007123021,0.0001570562,0.0001235688,0.0001447898,0.0003032075,0.0002460273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002479671,"about_ca_system_score_gemma":0.0001094382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004366026,"about_ca_topic_score_gemma":0.0005562697,"domain_scores_codex":[0.9999536,0.000007154961,0.000002508348,0.000008466958,0.00001270156,0.00001546246],"domain_scores_gemma":[0.999965,0.000003070945,0.0000116157,0.000002679415,0.000004936971,0.00001280819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001134969,0.00001095871,0.0002159653,0.00003142473,0.000004504939,0.0001656432,0.000005853802,0.00003189757,0.9979526,0.00004896283,0.00003389318,0.001384851],"study_design_scores_gemma":[0.00005372446,0.0005460415,0.03669795,0.00001610833,0.00004556141,0.001535658,0.00009230995,0.001913297,0.9562263,0.0001652048,0.002698557,0.000009315074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927236,0.003697932,0.001822025,0.00009828559,0.00002922537,0.00001492474,0.0001158468,0.00005233381,0.001445752],"genre_scores_gemma":[0.9948815,0.002545261,0.0009199143,0.00002853385,0.00001489141,0.00001243484,0.0001206293,0.000005288036,0.001471505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006344522,"threshold_uncertainty_score":0.002122462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007954717486670336,"score_gpt":0.1911446216988391,"score_spread":0.1831899042121688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}