{"id":"W2128112010","doi":"10.1074/mcp.m600468-mcp200","title":"Proteomics Analysis of Interleukin (IL)-7-induced Signaling Effectors Shows Selective Changes in IL-7Rα449F Knock-in T Cell Progenitors","year":2007,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"British Columbia Knowledge Development Fund; Michael Smith Health Research BC; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Cell biology; Progenitor cell; Interleukin 15; Effector; Proteomics; Biology; Interleukin 4; Gene knockin; Interleukin; Signal transduction; Cytokine; Stem cell; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001448589,0.0004520647,0.0008303273,0.001843412,0.00009024416,0.00002791375,0.0003488785,0.0006348331,0.000162198],"category_scores_gemma":[0.0001488171,0.0004774246,0.0003851144,0.00179201,0.0001016145,0.0001174409,0.0001226355,0.0009788683,0.00005152973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000456884,"about_ca_system_score_gemma":0.0001038938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005853536,"about_ca_topic_score_gemma":0.0007125966,"domain_scores_codex":[0.9968734,0.0005729473,0.0009963192,0.0006920762,0.0001239791,0.0007412348],"domain_scores_gemma":[0.998646,0.0001231644,0.000530356,0.0004685989,0.0001840911,0.00004777706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007754886,0.0004260513,0.007411286,0.00007351225,0.0005802164,0.000052176,0.001188541,0.0005629387,0.9882435,0.0000379579,0.00001362496,0.0006347405],"study_design_scores_gemma":[0.001530221,0.0005538553,0.0008706558,0.00007660756,0.0003298122,0.00001098639,0.000538804,0.0004863953,0.9947514,0.00002243116,0.0003904358,0.000438407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851591,0.0004010407,0.01090714,0.00003318227,0.0008792749,0.002167419,0.00001081788,0.00005969141,0.0003823404],"genre_scores_gemma":[0.9979865,0.00001419765,0.0009602644,0.00007141475,0.00002899257,0.0001919503,0.000222338,0.00006461061,0.0004597066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01282743,"threshold_uncertainty_score":0.9997677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008140538360738464,"score_gpt":0.2255197949703029,"score_spread":0.2173792566095644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}