{"id":"W2128146649","doi":"10.1096/fj.08-127688","title":"Pore formation by <i>Vibrio cholerae</i> cytolysin follows the same archetypical mode as β‐barrel toxins from gram‐positive organisms","year":2009,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Deutsche Forschungsgemeinschaft","keywords":"Cytolysin; Vibrio cholerae; Pore-forming toxin; Trimer; Membrane; Transmembrane protein; Chemistry; Mutant; Monomer; Biochemistry; Biophysics; Oligomer; Peptide sequence; Toxin; Biology; Bacteria; Dimer; Microbial toxins; Polymer chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001413469,0.0002645043,0.0001356162,0.00009134039,0.0001388902,0.0003799316,0.0001550433,0.0002331825,0.0004532725],"category_scores_gemma":[0.0002044765,0.0001087674,0.0001985691,0.0000810963,0.0003402125,0.0002828031,0.0001623375,0.000416369,0.0003570167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004169408,"about_ca_system_score_gemma":0.0002885077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001088324,"about_ca_topic_score_gemma":0.0008281711,"domain_scores_codex":[0.9998958,0.00001613933,0.000008227564,0.00002696464,0.00003013754,0.00002274725],"domain_scores_gemma":[0.9998555,0.00002893278,0.00004461449,0.00001829373,0.00002687271,0.00002578368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000164244,0.000005685624,0.0002192229,0.00001476343,0.00000204308,0.00002940082,0.00001598952,0.00002535314,0.9992816,0.0001385169,0.000008123692,0.0002428632],"study_design_scores_gemma":[0.000003707988,0.0000568627,0.003696284,0.000002764956,0.000004185456,0.0002740066,0.00003332918,0.000362915,0.9946671,0.00007512644,0.0008212327,0.000002649302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942894,0.0005552424,0.003797055,0.00006347643,0.0000108178,0.00001813811,0.00008642943,0.00004195248,0.001137485],"genre_scores_gemma":[0.9963941,0.0003369388,0.001899893,0.00003930446,0.000002713365,0.00001504456,0.0002537724,0.00001382735,0.001044366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001088324,"threshold_uncertainty_score":0.003025115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009131105241547826,"score_gpt":0.2614822702929989,"score_spread":0.2523511650514511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}