{"id":"W2128146649","doi":"10.1096/fj.08-127688","title":"Pore formation by <i>Vibrio cholerae</i> cytolysin follows the same archetypical mode as β‐barrel toxins from gram‐positive organisms","year":2009,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Deutsche Forschungsgemeinschaft","keywords":"Cytolysin; Vibrio cholerae; Pore-forming toxin; Trimer; Membrane; Transmembrane protein; Chemistry; Mutant; Monomer; Biochemistry; Biophysics; Oligomer; Peptide sequence; Toxin; Biology; Bacteria; Dimer; Microbial toxins; Polymer chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004178156,0.0002138859,0.0001913858,0.00002535209,0.0006311529,0.0002089755,0.0005415982,0.0001166796,0.0000443571],"category_scores_gemma":[0.0001670393,0.0001218811,0.0001804589,0.0001030809,0.0002027828,0.00002483735,0.0001537292,0.0004995989,0.00003464871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006289642,"about_ca_system_score_gemma":0.0001122116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005849,"about_ca_topic_score_gemma":0.00003574956,"domain_scores_codex":[0.9983564,0.0003242168,0.0002885659,0.0002194744,0.0003858373,0.0004255048],"domain_scores_gemma":[0.9991491,0.00005335913,0.0001543132,0.0003682968,0.0001222539,0.0001526537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002779294,0.00006672375,0.0000518756,0.000001074306,0.0001291333,0.00001334778,0.0007250753,0.00002647866,0.9838225,0.00005041207,0.009952384,0.004883124],"study_design_scores_gemma":[0.001014016,0.0004586439,0.002917852,0.00002804343,0.00006141966,0.0003281867,0.000731689,0.0002005883,0.9873704,0.001952106,0.004719552,0.0002174476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828533,0.0009021041,0.006096085,0.008919206,0.0001016498,0.0002468805,0.0001417518,0.00001286722,0.0007261891],"genre_scores_gemma":[0.9955114,0.0006230098,0.0002690195,0.002358363,0.0005067386,0.000007858704,0.0002759557,0.0000189921,0.000428697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0126581,"threshold_uncertainty_score":0.4970165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009131105241547826,"score_gpt":0.2614822702929989,"score_spread":0.2523511650514511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}