{"id":"W2128161895","doi":"10.1186/2040-2392-3-9","title":"Common genetic variants, acting additively, are a major source of risk for autism","year":2012,"lang":"en","type":"article","venue":"Molecular Autism","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":432,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Fondation de France; Hospital for Sick Children; Ministero della Salute; Fondation pour la Recherche Médicale; Simons Foundation Autism Research Initiative; Johns Hopkins University; Autism Speaks; Sick Kids Foundation; Fondation Orange; National Institutes of Health; Fondation FondaMental; NODAI Genome Research Center, Tokyo University of Agriculture; Wellcome Trust; Koninklijke Nederlandse Akademie van Wetenschappen; Hussman Foundation; University of Toronto; Yale University; Institut National de la Santé et de la Recherche Médicale; Simons Foundation; Deutsche Forschungsgemeinschaft; Ontario Innovation Trust","keywords":"Heritability; Missing heritability problem; Autism; Genetic variation; Genetics; Multiplex; Allele; Psychology; Biology; Developmental psychology; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001130459,0.0007070245,0.0007189544,0.001830537,0.0004799704,0.0007105281,0.0004551983,0.0005118333,0.002955602],"category_scores_gemma":[0.004454688,0.0004368902,0.001076377,0.001001987,0.0008505313,0.0004317083,0.001120723,0.0006216852,0.0002330352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002627937,"about_ca_system_score_gemma":0.0003215702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002251504,"about_ca_topic_score_gemma":0.002387047,"domain_scores_codex":[0.9979006,0.0004531341,0.0001967526,0.0008433813,0.0004764736,0.0001296471],"domain_scores_gemma":[0.9960371,0.001816305,0.0009990255,0.0007622105,0.0001958921,0.0001895265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001126485,0.0001428787,0.8846283,0.0001280843,0.002416995,0.001753972,0.0005358806,0.002605835,0.07397947,0.002401286,0.0002611548,0.03001966],"study_design_scores_gemma":[0.00002104115,0.0002723669,0.9812602,0.00003244325,0.001164285,0.003422985,0.000198531,0.003586609,0.005467254,0.00381543,0.0007269445,0.00003183844],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984353,0.0006515716,0.01330341,0.00008702638,0.00001427332,0.00002078436,0.0002481838,0.0001215833,0.001200066],"genre_scores_gemma":[0.9967504,0.0001677949,0.002670146,0.00002127389,0.00001188649,0.00001006908,0.0001464654,0.00002161911,0.0002004459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002955602,"threshold_uncertainty_score":0.009887516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02212714667080427,"score_gpt":0.2848407743407746,"score_spread":0.2627136276699703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}