{"id":"W2128161895","doi":"10.1186/2040-2392-3-9","title":"Common genetic variants, acting additively, are a major source of risk for autism","year":2012,"lang":"en","type":"article","venue":"Molecular Autism","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":432,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Fondation de France; Hospital for Sick Children; Ministero della Salute; Fondation pour la Recherche Médicale; Simons Foundation Autism Research Initiative; Johns Hopkins University; Autism Speaks; Sick Kids Foundation; Fondation Orange; National Institutes of Health; Fondation FondaMental; NODAI Genome Research Center, Tokyo University of Agriculture; Wellcome Trust; Koninklijke Nederlandse Akademie van Wetenschappen; Hussman Foundation; University of Toronto; Yale University; Institut National de la Santé et de la Recherche Médicale; Simons Foundation; Deutsche Forschungsgemeinschaft; Ontario Innovation Trust","keywords":"Heritability; Missing heritability problem; Autism; Genetic variation; Genetics; Multiplex; Allele; Psychology; Biology; Developmental psychology; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004180005,0.0002938547,0.0004069363,0.0002239584,0.0003493384,0.00005629723,0.0006074111,0.0001725286,0.0002275376],"category_scores_gemma":[0.0009195758,0.0003113894,0.0002231737,0.0004716495,0.0002193154,0.0002118345,0.0003463294,0.0004416979,0.0001047272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000789074,"about_ca_system_score_gemma":0.00006798394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000282511,"about_ca_topic_score_gemma":0.00002008404,"domain_scores_codex":[0.996816,0.0004798821,0.0004253588,0.0005682195,0.0006191332,0.001091417],"domain_scores_gemma":[0.998058,0.0005907963,0.0004260133,0.0006575555,0.00001162723,0.0002560717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001499578,0.0007974718,0.005822398,0.0001994914,0.00009687214,0.0001284784,0.003048221,0.0001749304,0.8428858,0.1121378,0.0004844579,0.03407412],"study_design_scores_gemma":[0.002349475,0.0002366278,0.6222786,0.0001416899,0.0001512308,0.0001273042,0.0001566276,0.004995102,0.3316749,0.02881129,0.00827587,0.0008013372],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8874243,0.000989564,0.1059715,0.001912796,0.0003070054,0.001236166,0.0003900797,0.0001828935,0.001585659],"genre_scores_gemma":[0.9964056,0.00004445677,0.002793531,0.0002404624,0.00001768597,0.0001347899,0.000009728729,0.0001040271,0.000249716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6164562,"threshold_uncertainty_score":0.9999338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02212714667080427,"score_gpt":0.2848407743407746,"score_spread":0.2627136276699703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}