{"id":"W2128168096","doi":"10.1158/1078-0432.ccr-05-1167","title":"Effects of HIV Protease Inhibitor Ritonavir on Akt-Regulated Cell Proliferation in Breast Cancer","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute","keywords":"Ritonavir; Protein kinase B; Cell growth; Cancer research; Chemistry; Growth inhibition; Cyclin D1; Biology; Apoptosis; Biochemistry; Cell cycle; Virology; Virus; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002661719,0.0002772112,0.000355828,0.0002266458,0.0001716674,0.0003839098,0.0002820905,0.0002432579,0.001609663],"category_scores_gemma":[0.0001832664,0.0001398645,0.0002498659,0.000242481,0.0001628663,0.0002301665,0.0001127223,0.0005439651,0.000407288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003935111,"about_ca_system_score_gemma":0.0003068004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007280393,"about_ca_topic_score_gemma":0.0018247,"domain_scores_codex":[0.9998111,0.00006495076,0.00001727625,0.00001932546,0.0000445773,0.00004275961],"domain_scores_gemma":[0.9999242,0.00002611574,0.00001414316,0.0000121558,0.00001303374,0.00001034344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003482939,0.001020631,0.002490429,0.0004190841,0.0000710097,0.0001773807,0.00007642664,0.0006904516,0.9436408,0.0004394346,0.0005352766,0.04695616],"study_design_scores_gemma":[0.0003088782,0.006397465,0.01816023,0.0000408444,0.0001205106,0.0006614723,0.00008767996,0.002288501,0.9629302,0.0001200934,0.008870483,0.00001359359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978284,0.01549228,0.0005770681,0.000198466,0.00007408668,0.00006488545,0.0003832986,0.00008865333,0.004837257],"genre_scores_gemma":[0.9873387,0.008554136,0.001249049,0.0001245894,0.00002311896,0.00005502703,0.000586974,0.00001566345,0.002052826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001609663,"threshold_uncertainty_score":0.005384803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03742455038747397,"score_gpt":0.4229952260042277,"score_spread":0.3855706756167537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}