{"id":"W2128192593","doi":"10.1093/hmg/ddu387","title":"Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Japan Science and Technology Agency; National Institute for Health and Care Research; Japan Society for the Promotion of Science; Arthritis Foundation","keywords":"Biology; Allele; Human leukocyte antigen; Genetics; Imputation (statistics); Major histocompatibility complex; Rheumatoid arthritis; Allele frequency; Genotype; Concordance; Immunology; Gene; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000156006,0.0002676802,0.0003294491,0.0001399535,0.0003520677,0.00003965456,0.0002513945,0.0002509824,0.0001337018],"category_scores_gemma":[0.0000362344,0.0002962345,0.0001019761,0.00008409021,0.0002842071,0.0000367311,0.0001494376,0.0002822976,0.0001259968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002326216,"about_ca_system_score_gemma":0.00001431047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007353081,"about_ca_topic_score_gemma":0.0001403914,"domain_scores_codex":[0.9981871,0.0004498692,0.0003924512,0.0004824548,0.0000369013,0.000451208],"domain_scores_gemma":[0.9993098,0.00002876045,0.0001740512,0.0003887496,0.00005627915,0.0000423867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002333078,0.00009995844,0.003964134,0.000004352118,0.00008529205,0.000007681406,0.0007222859,0.00000366139,0.9801232,0.0007140781,0.001894115,0.01235795],"study_design_scores_gemma":[0.004864342,0.0008607565,0.07753253,0.00008888292,0.00006834696,0.00009332796,0.0001264495,0.00005711451,0.8912057,0.002361663,0.02207904,0.0006618141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776956,0.01510873,0.00480263,0.0002145833,0.0001937601,0.0004232435,0.0003128869,0.0000532587,0.00119533],"genre_scores_gemma":[0.9966826,0.000658638,0.0009394038,0.0003062245,0.0000172953,0.00002941416,0.0008820947,0.00005758313,0.0004267139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08891743,"threshold_uncertainty_score":0.999949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009636609228777132,"score_gpt":0.220043154764375,"score_spread":0.2104065455355978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}