{"id":"W2128192593","doi":"10.1093/hmg/ddu387","title":"Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Japan Science and Technology Agency; National Institute for Health and Care Research; Japan Society for the Promotion of Science; Arthritis Foundation","keywords":"Biology; Allele; Human leukocyte antigen; Genetics; Imputation (statistics); Major histocompatibility complex; Rheumatoid arthritis; Allele frequency; Genotype; Concordance; Immunology; Gene; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001598561,0.0004555638,0.0004466033,0.0006707535,0.0004075605,0.000789761,0.0004500965,0.0004723348,0.002406149],"category_scores_gemma":[0.004327264,0.0002692121,0.000719047,0.001133136,0.0005559948,0.0002789396,0.0005890898,0.0005549245,0.0003895671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000140467,"about_ca_system_score_gemma":0.0002106134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002940874,"about_ca_topic_score_gemma":0.002062345,"domain_scores_codex":[0.9986668,0.0005982828,0.0001179305,0.0003804661,0.0001365,0.00009991905],"domain_scores_gemma":[0.9978187,0.0007273084,0.0006295327,0.0003855783,0.0001893563,0.0002495787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005907031,0.00003902803,0.9863153,0.00002165056,0.0003313209,0.0003335859,0.0002814164,0.0001989719,0.004286335,0.0001701679,0.0001441246,0.007287482],"study_design_scores_gemma":[0.00002302259,0.0001015878,0.9968243,0.00001055137,0.0001669487,0.001098737,0.000172117,0.0007878864,0.0003022289,0.0002693911,0.0002348667,0.000008581527],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982292,0.0003853156,0.0005919613,0.00004253285,0.000006444224,0.000006507986,0.0001104659,0.00001419765,0.0006134429],"genre_scores_gemma":[0.999233,0.0001249129,0.0003729894,0.00002671698,0.000009306189,0.000005113479,0.0001242342,0.000006995452,0.00009673025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002940874,"threshold_uncertainty_score":0.008454144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009636609228777132,"score_gpt":0.220043154764375,"score_spread":0.2104065455355978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}