{"id":"W2128242002","doi":"10.1172/jci34672","title":"VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Institute on Alcohol Abuse and Alcoholism; University of Toronto; U.S. Army Medical Research Acquisition Activity; National Institutes of Health; King's College London","keywords":"Exocytosis; Cell biology; Secretion; Zymogen; Epithelial polarity; Acinar cell; Chemistry; Syntaxin; Biology; Internal medicine; Endocrinology; Biochemistry; Pancreas; Medicine; Cell; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004043464,0.001287034,0.0007177701,0.001577026,0.0005952499,0.0005778904,0.0007013381,0.001621412,0.003764302],"category_scores_gemma":[0.0002316714,0.0005600586,0.0008062653,0.0005289158,0.0007932172,0.0009921096,0.0006199359,0.002363337,0.001173079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007630643,"about_ca_system_score_gemma":0.0003778963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007201706,"about_ca_topic_score_gemma":0.0008925318,"domain_scores_codex":[0.9994391,0.00008514513,0.00009002627,0.0001484398,0.0001329532,0.0001043291],"domain_scores_gemma":[0.9995999,0.00002477999,0.0001491113,0.00004002162,0.00002983694,0.0001564709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009392178,0.000329557,0.00054416,0.0000870331,0.00001937807,0.0004146004,0.00004312028,0.0001137237,0.995284,0.0004361442,0.0001992206,0.001589847],"study_design_scores_gemma":[0.000491005,0.003772147,0.01244864,0.0001046906,0.0001475765,0.00468514,0.0002510165,0.004048697,0.9633002,0.0006968533,0.01000994,0.00004405752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982374,0.002414432,0.009012533,0.0008535723,0.0002391919,0.00024696,0.002255835,0.0006889018,0.001914689],"genre_scores_gemma":[0.9766019,0.002747523,0.007140114,0.0003251851,0.0000711856,0.0007648877,0.002227855,0.0001706148,0.009950802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003764302,"threshold_uncertainty_score":0.01259285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1692754942641517,"score_gpt":0.3563864009225822,"score_spread":0.1871109066584306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}