{"id":"W2128251606","doi":"10.1177/1740774514558307","title":"Unsuccessful trial accrual and human subjects protections: An empirical analysis of recently closed trials","year":2014,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":387,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Accrual; Clinical trial; Medicine; Placebo; Sample size determination; Randomized controlled trial; Family medicine; Internal medicine; Alternative medicine; Accounting; Pathology; Statistics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":["metaresearch","research_integrity"],"category_scores_codex":[0.3246425,0.0003472408,0.007248066,0.0007707733,0.0002303583,0.0001186839,0.0005153968,0.001854925,0.0008797914],"category_scores_gemma":[0.7760038,0.0002483941,0.002324508,0.001772244,0.001229611,0.000148756,0.0002485628,0.002986158,0.00002436419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005831374,"about_ca_system_score_gemma":0.0007899248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001277271,"about_ca_topic_score_gemma":0.0003422554,"domain_scores_codex":[0.9505555,0.03481382,0.01065935,0.00146584,0.001917537,0.0005879328],"domain_scores_gemma":[0.5170389,0.4708009,0.004798692,0.003213318,0.002185265,0.001962917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4622098,0.01793992,0.3074745,0.001061149,0.02286366,0.00005553738,0.0005008884,0.0000291543,0.007337197,0.02317346,0.00283726,0.1545175],"study_design_scores_gemma":[0.4143423,0.05294071,0.3533142,0.0008151627,0.03022445,0.000008026571,0.0003282554,0.001406566,0.004215653,0.1294293,0.01179192,0.00118339],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881576,0.0001157038,0.0008466761,0.003990897,0.0009882691,0.004389782,0.00004985941,0.0001123483,0.001348893],"genre_scores_gemma":[0.9922218,0.0006446588,0.001450324,0.0009168437,0.003838613,0.0001960536,0.00009322396,0.00004899604,0.0005894921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4513613,"threshold_uncertainty_score":0.9999968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.891537863837492,"score_gpt":0.7465437281129513,"score_spread":0.1449941357245407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}