{"id":"W2128251606","doi":"10.1177/1740774514558307","title":"Unsuccessful trial accrual and human subjects protections: An empirical analysis of recently closed trials","year":2014,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":387,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Accrual; Clinical trial; Medicine; Placebo; Sample size determination; Randomized controlled trial; Family medicine; Internal medicine; Alternative medicine; Accounting; Pathology; Statistics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","research_integrity"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.5099979,0.0006811234,0.002097989,0.003804921,0.002413781,0.004936631,0.004213274,0.003195395,0.00427175],"category_scores_gemma":[0.8476222,0.0008404928,0.004713568,0.004827423,0.01229219,0.008528502,0.005684306,0.005671823,0.0004127857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003519995,"about_ca_system_score_gemma":0.005691706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001011931,"about_ca_topic_score_gemma":0.0009046195,"domain_scores_codex":[0.3907002,0.4976086,0.05019734,0.0173763,0.04093983,0.003177674],"domain_scores_gemma":[0.02699971,0.8346528,0.1004385,0.02949372,0.006756878,0.001658467],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008563785,0.000589812,0.8646998,0.003664434,0.006105908,0.0008546814,0.008745062,0.002374841,0.0002876897,0.02157549,0.002659887,0.07987871],"study_design_scores_gemma":[0.002310476,0.01066285,0.8504803,0.007156012,0.007642421,0.005801322,0.005854581,0.02644701,0.001855381,0.05701536,0.02447405,0.000300304],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8700433,0.02750361,0.071358,0.009159652,0.0003285108,0.006688932,0.001620206,0.0001499769,0.01314781],"genre_scores_gemma":[0.9872479,0.0007013281,0.008574307,0.0009264066,0.000145705,0.001713399,0.0002872628,0.00005344576,0.0003502782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9968046,"threshold_uncertainty_score":0.6042598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.891537863837492,"score_gpt":0.7465437281129513,"score_spread":0.1449941357245407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}