{"id":"W2128252950","doi":"10.1016/j.biomaterials.2009.06.010","title":"The binding of pullulan modified cholesteryl nanogels to Aβ oligomers and their suppression of cytotoxicity","year":2009,"lang":"en","type":"article","venue":"Biomaterials","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Pullulan; Cytotoxicity; Monomer; Oligomer; Biophysics; Chemistry; Amyloid (mycology); Amyloid beta; Biochemistry; Organic chemistry; In vitro; Polymer; Peptide; Biology; Polysaccharide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002304088,0.0001195592,0.0003030811,0.00008829288,0.00007898382,0.00002281527,0.00008382431,0.00005228891,0.00001501665],"category_scores_gemma":[0.00005158151,0.00006338743,0.00005291015,0.000105115,0.00008496881,0.00004524417,0.00004673747,0.000008250609,0.000005802208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001848784,"about_ca_system_score_gemma":0.0000414765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003161516,"about_ca_topic_score_gemma":6.827622e-7,"domain_scores_codex":[0.9990925,0.00007232223,0.00026683,0.0001563987,0.0001853606,0.0002266306],"domain_scores_gemma":[0.9993504,0.00005048345,0.00009822149,0.000255936,0.00005377171,0.0001911409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007196328,0.0001110749,0.001333056,0.0000437163,0.000388584,0.000007000744,0.0001873949,1.697501e-7,0.9960785,0.00003639037,0.00006094932,0.001033548],"study_design_scores_gemma":[0.0008301968,0.0004019052,0.05410421,0.0001609085,0.00005187267,0.000008309696,0.00009427154,0.000004183834,0.9441757,0.00009367714,0.00002217174,0.00005259152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982814,0.0005695557,0.000005237859,0.0002697173,0.00005772076,0.0005396659,0.0001424697,0.00001699867,0.000117235],"genre_scores_gemma":[0.9997309,0.0001001646,0.00004218979,0.00002795067,0.00003398215,0.00001293517,0.00002688811,0.000008611299,0.00001639314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05277116,"threshold_uncertainty_score":0.2584864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03305040010861479,"score_gpt":0.3140161260782786,"score_spread":0.2809657259696638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}