{"id":"W2128294133","doi":"10.1085/jgp.201210788","title":"Inorganic polyphosphate is a potent activator of the mitochondrial permeability transition pore in cardiac myocytes","year":2012,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; Fondation Leducq; National Institutes of Health; Rush University; Loyola University Chicago; American Heart Association","keywords":"Mitochondrial permeability transition pore; MPTP; Mitochondrion; Myocyte; Cytosol; Polyphosphate; Inner mitochondrial membrane; Adenosine triphosphate; Mitochondrial membrane transport protein; Cell biology; Chemistry; Membrane potential; Biology; Biochemistry; Biophysics; Programmed cell death; Endocrinology; Enzyme; Apoptosis; Phosphate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004152775,0.0001456498,0.0005111927,0.00005880669,0.00007444959,0.000003192948,0.0001714795,0.0001039089,0.00009586581],"category_scores_gemma":[0.00006441246,0.00007697652,0.0003504714,0.0002006952,0.0001850598,0.0001330441,0.00003830425,0.0002740556,0.000002427291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000084277,"about_ca_system_score_gemma":0.0001524842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002146933,"about_ca_topic_score_gemma":0.00000556693,"domain_scores_codex":[0.9985478,0.0003290815,0.0005166118,0.00009479542,0.0002393965,0.0002722983],"domain_scores_gemma":[0.9990239,0.0001008421,0.0003698045,0.0002809616,0.0001333535,0.00009116677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001289256,0.0002317429,0.01497394,0.00003312248,0.0001394815,7.550701e-7,0.004466129,0.0001016633,0.9767128,0.00006969067,0.0008099095,0.001171526],"study_design_scores_gemma":[0.001101748,0.0002557292,0.7327595,0.0000517613,0.0001819936,0.00006254889,0.0002845377,0.00006273836,0.2641515,0.0007368745,0.0002772,0.00007383235],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932289,0.002574301,0.00001773358,0.002909631,0.0009958021,0.0002304912,0.00001147688,0.000004579153,0.00002708445],"genre_scores_gemma":[0.9973865,0.0002170455,0.00009691656,0.0007211152,0.001479201,0.000001934271,0.000004471178,0.00001464706,0.00007819073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7177855,"threshold_uncertainty_score":0.3139012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267713329365865,"score_gpt":0.2499392821480176,"score_spread":0.237262148854359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}