{"id":"W2128304515","doi":"10.1161/01.res.0000043282.39776.7c","title":"Gα <sub>12/13</sub> Mediates α <sub>1</sub> -Adrenergic Receptor–Induced Cardiac Hypertrophy","year":2002,"lang":"en","type":"article","venue":"Circulation Research","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Pertussis toxin; G protein; Protein kinase A; Cell biology; Heterotrimeric G protein; GTP-binding protein regulators; Kinase; Gq alpha subunit; Gs alpha subunit; Biology; Receptor; Protein subunit; Molecular biology; G alpha subunit; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001099432,0.0003077807,0.0003333098,0.0002795518,0.0004687937,0.0001578123,0.0003730637,0.00049284,0.0003012675],"category_scores_gemma":[0.0003724043,0.0003130418,0.0002780874,0.0004971809,0.0001333314,0.00002386284,0.0001919869,0.0004552101,0.0004406315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009359758,"about_ca_system_score_gemma":0.0001018019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003946043,"about_ca_topic_score_gemma":0.00001856106,"domain_scores_codex":[0.9963464,0.0005421396,0.000443304,0.0008600951,0.0009626138,0.0008454862],"domain_scores_gemma":[0.9982484,0.00009694134,0.0001123716,0.0006980734,0.0005104986,0.0003336926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003840974,0.00007807142,0.0009211901,0.00002589239,0.00007813152,0.000005205782,0.0001020324,0.0008481545,0.9752583,0.0001001323,0.002964598,0.01957987],"study_design_scores_gemma":[0.0004901448,0.0002528773,0.002056125,0.00002807058,0.00001693022,0.000005108706,0.00009927151,0.002271642,0.9915086,0.0002081956,0.002687782,0.0003752743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948063,0.001880059,0.0003068309,0.0002029532,0.0006094308,0.0004655965,0.00002282079,0.00005173169,0.00165427],"genre_scores_gemma":[0.9962493,0.001640682,0.00008589501,0.00008482659,0.001260886,0.0001216229,0.0003499581,0.00008642219,0.0001204085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01920459,"threshold_uncertainty_score":0.9999322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05476263559659067,"score_gpt":0.2829803910912199,"score_spread":0.2282177554946292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}