{"id":"W2128304515","doi":"10.1161/01.res.0000043282.39776.7c","title":"Gα <sub>12/13</sub> Mediates α <sub>1</sub> -Adrenergic Receptor–Induced Cardiac Hypertrophy","year":2002,"lang":"en","type":"article","venue":"Circulation Research","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Pertussis toxin; G protein; Protein kinase A; Cell biology; Heterotrimeric G protein; GTP-binding protein regulators; Kinase; Gq alpha subunit; Gs alpha subunit; Biology; Receptor; Protein subunit; Molecular biology; G alpha subunit; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002172424,0.0007208532,0.0003878244,0.0002464139,0.0002482994,0.0003438678,0.0002535008,0.0002257523,0.001802425],"category_scores_gemma":[0.000101189,0.0002759394,0.0005957905,0.000164693,0.0004742217,0.0002415378,0.0003093917,0.001087451,0.001358786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006241814,"about_ca_system_score_gemma":0.0003260728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009276311,"about_ca_topic_score_gemma":0.0017344,"domain_scores_codex":[0.9998529,0.00002789379,0.00000894605,0.00002090451,0.00002320475,0.00006608535],"domain_scores_gemma":[0.9998754,0.00001635661,0.00003429609,0.00001677918,0.00001142313,0.00004568381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003140749,0.00005351245,0.0001592675,0.00005328538,0.000007930746,0.00006783841,0.0000158553,0.00005901811,0.9981335,0.0001659354,0.0001107679,0.000858889],"study_design_scores_gemma":[0.000227463,0.0009710252,0.02729751,0.00003491739,0.00006921956,0.0007036673,0.0001195943,0.002293909,0.9611598,0.0002482131,0.006860944,0.00001375172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900837,0.0032073,0.002091303,0.0002519414,0.00009503614,0.00005929382,0.0005846774,0.0001115972,0.003515114],"genre_scores_gemma":[0.9869295,0.003899041,0.002063499,0.0003308829,0.00007904317,0.0001127625,0.00186011,0.00008275457,0.004642326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001802425,"threshold_uncertainty_score":0.006029665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05476263559659067,"score_gpt":0.2829803910912199,"score_spread":0.2282177554946292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}