{"id":"W2128367294","doi":"10.1016/j.stem.2012.03.016","title":"Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation","year":2012,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":471,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research","keywords":"Neurogenesis; Neural stem cell; Biology; Metformin; Neuroscience; Stem cell; Cell biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002334313,0.0003328586,0.0002843781,0.0001251109,0.0002881036,0.0001063584,0.0003062234,0.0001035273,0.00005597717],"category_scores_gemma":[0.00003839997,0.0003021681,0.0000725517,0.0002585207,0.00004333531,0.0008024657,0.0002139176,0.0001681491,0.0002682855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003087071,"about_ca_system_score_gemma":0.00002618033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006023026,"about_ca_topic_score_gemma":0.000004084879,"domain_scores_codex":[0.9976302,0.0002873238,0.0003633057,0.0006365018,0.0004054025,0.0006772777],"domain_scores_gemma":[0.9985967,0.0002358328,0.0001685261,0.0004106525,0.00003525155,0.0005529997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000108867,0.0002784913,0.00003117656,0.00007598402,7.657712e-7,0.00001794891,0.0005187204,0.00001412602,0.9858392,0.00008325883,0.00002053731,0.01301093],"study_design_scores_gemma":[0.0002679869,0.0004625226,0.0002644027,0.0000097281,0.00001894564,0.00005522805,0.00006555331,0.0006053323,0.9945546,0.000006975205,0.003372024,0.0003166681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942625,0.00006151113,0.003350231,0.00002944819,0.0006042864,0.0006772015,0.00002158015,0.0001355251,0.0008577027],"genre_scores_gemma":[0.9981029,0.00005157917,0.000268956,0.0006259663,0.0001791259,0.00005258025,0.000002664466,0.00006579485,0.0006504225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01269426,"threshold_uncertainty_score":0.999943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02833598992848175,"score_gpt":0.2393775231962702,"score_spread":0.2110415332677885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}