{"id":"W2128404583","doi":"10.1002/gepi.21760","title":"Distinct Loci in the <i>CHRNA5</i>/<i>CHRNA3</i>/<i>CHRNB4</i> Gene Cluster Are Associated With Onset of Regular Smoking","year":2013,"lang":"en","type":"review","venue":"Genetic Epidemiology","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; National Center for Advancing Translational Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; Australian Research Council; National Institutes of Health","keywords":"Single-nucleotide polymorphism; Phenotype; Cotinine; Nicotine; Gene; Genetics; Genetic association; Biology; Internal medicine; Medicine; Oncology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003480621,0.000798343,0.004464664,0.0003535071,0.0001092091,0.00001447921,0.0006438683,0.001222417,0.0001323229],"category_scores_gemma":[0.002505983,0.0004710786,0.0006430103,0.0007909094,0.0004874122,0.00003954679,0.0001309493,0.001375118,0.00001418894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003302813,"about_ca_system_score_gemma":0.000279094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002515689,"about_ca_topic_score_gemma":0.0001002768,"domain_scores_codex":[0.9918042,0.003594359,0.002265456,0.0009317085,0.0005024872,0.0009017465],"domain_scores_gemma":[0.9921115,0.003611461,0.00243832,0.001450227,0.0002275577,0.0001609086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007961332,0.0005895052,0.5265892,0.008599603,0.0009692881,0.0003854848,0.0003450387,0.00004145813,0.00000468635,0.0000500529,0.01389686,0.4484492],"study_design_scores_gemma":[0.002711051,0.000860905,0.5755539,0.02415181,0.008332063,0.002201742,0.0001459292,0.00003396884,0.00001111736,0.0004496773,0.3843935,0.001154376],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04657131,0.9494932,0.0004256591,0.0003982826,0.0002861217,0.002437516,0.0001192171,0.00005767007,0.0002110301],"genre_scores_gemma":[0.02348873,0.9713014,0.0009129114,0.001510823,0.0003496892,0.0006991873,0.001329519,0.0001592785,0.0002485042],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4472948,"threshold_uncertainty_score":0.9997741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1000635224714826,"score_gpt":0.3590781656527755,"score_spread":0.2590146431812929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}