{"id":"W2128404583","doi":"10.1002/gepi.21760","title":"Distinct Loci in the <i>CHRNA5</i>/<i>CHRNA3</i>/<i>CHRNB4</i> Gene Cluster Are Associated With Onset of Regular Smoking","year":2013,"lang":"en","type":"review","venue":"Genetic Epidemiology","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; National Center for Advancing Translational Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; Australian Research Council; National Institutes of Health","keywords":"Single-nucleotide polymorphism; Phenotype; Cotinine; Nicotine; Gene; Genetics; Genetic association; Biology; Internal medicine; Medicine; Oncology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001770574,0.0005767494,0.000981602,0.001037467,0.0004392409,0.0008779513,0.0007173698,0.0006329987,0.0024922],"category_scores_gemma":[0.003814428,0.0003639337,0.005198617,0.00182529,0.0003888962,0.000291392,0.0006229856,0.0005474701,0.0002053058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003916494,"about_ca_system_score_gemma":0.0004497849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0104229,"about_ca_topic_score_gemma":0.01522861,"domain_scores_codex":[0.9983052,0.0005504346,0.0001839192,0.0006392736,0.0001888753,0.0001322983],"domain_scores_gemma":[0.997747,0.001249561,0.0005274065,0.0002783794,0.0001104785,0.00008719724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004419731,0.000041365,0.9063297,0.001382388,0.05810228,0.0003877961,0.0001881129,0.001079529,0.008714356,0.0003280558,0.0007793117,0.01824732],"study_design_scores_gemma":[0.0004124022,0.0003262245,0.9375495,0.0003020452,0.05482541,0.0005670741,0.0001730763,0.001188514,0.00165056,0.0006460481,0.002330378,0.00002859489],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9553602,0.03582108,0.003722218,0.0004518921,0.0001242229,0.00005707752,0.002556271,0.000108657,0.001798317],"genre_scores_gemma":[0.9948427,0.002623004,0.001159494,0.0001173271,0.00004301246,0.00002939863,0.0008614946,0.00002596425,0.0002975696],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0104229,"threshold_uncertainty_score":0.02072442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1000635224714826,"score_gpt":0.3590781656527755,"score_spread":0.2590146431812929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}