{"id":"W2128452890","doi":"10.1158/1078-0432.ccr-05-2148","title":"Gefitinib Inhibits the Growth and Invasion of Urothelial Carcinoma Cell Lines in which Akt and MAPK Activation Is Dependent on Constitutive Epidermal Growth Factor Receptor Activation","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Gefitinib; Protein kinase B; MAPK/ERK pathway; Epidermal growth factor receptor; Cancer research; Epidermal growth factor; Cell growth; EGFR inhibitors; PI3K/AKT/mTOR pathway; Tyrosine kinase; Kinase; Biology; Cell culture; Chemistry; Medicine; Phosphorylation; Internal medicine; Signal transduction; Cancer; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001205475,0.0001837551,0.0002586972,0.0001732987,0.0001602237,0.00005331444,0.0002283089,0.0003231115,0.00003882563],"category_scores_gemma":[0.001835551,0.0001393724,0.00005519402,0.0003516734,0.0006452087,0.00002916784,0.000343182,0.000736162,0.000004540887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005876951,"about_ca_system_score_gemma":0.0004561548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002137772,"about_ca_topic_score_gemma":0.000352027,"domain_scores_codex":[0.997032,0.000736003,0.0005388951,0.0006557514,0.0006142177,0.0004231605],"domain_scores_gemma":[0.9979041,0.0009222098,0.0001417741,0.0002726561,0.000640857,0.0001183795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001483134,0.0002133889,0.2113344,0.0001415349,0.00001481843,8.86016e-7,0.0001060636,0.000005456023,0.7850124,0.0002034171,0.0006861702,0.0007983386],"study_design_scores_gemma":[0.001354043,0.00075158,0.2044235,0.00009548582,0.000002824944,7.615437e-7,0.00007516809,0.0000264564,0.7927439,0.0001866484,0.0002222079,0.0001175006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961158,0.0001434932,0.00003394529,0.002258491,0.00006212148,0.0007577785,0.0001146094,0.000005360389,0.0005083858],"genre_scores_gemma":[0.9985837,0.000532408,0.00004616864,0.0001517785,0.0004013223,0.00008840662,0.00005269129,0.00002510767,0.0001184261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007731459,"threshold_uncertainty_score":0.568344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08137028910011788,"score_gpt":0.3888915653661901,"score_spread":0.3075212762660722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}