{"id":"W2128459026","doi":"10.4049/jimmunol.165.10.5750","title":"Modulation of Innate and Acquired Immune Responses by <i>Escherichia coli</i> Heat-Labile Toxin: Distinct Pro- and Anti-Inflammatory Effects of the Nontoxic AB Complex and the Enzyme Activity","year":2000,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College; Institute of Infection and Immunity","funders":"","keywords":"In vivo; Pertussis toxin; Immune system; Innate immune system; Cytokine; Escherichia coli; Bordetella pertussis; Enzyme; In vitro; Biology; Secretion; Adjuvant; Tumor necrosis factor alpha; Microbiology; Chemistry; Signal transduction; Biochemistry; Immunology; Bacteria; G protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001715725,0.0003883396,0.0002215735,0.00008324418,0.00006100745,0.0002414661,0.00009996244,0.0002168104,0.0004949001],"category_scores_gemma":[0.0001099846,0.00007735886,0.000221447,0.00007765976,0.0002296129,0.0001728908,0.0001212819,0.0003495647,0.0001572693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001660879,"about_ca_system_score_gemma":0.0001236838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001596165,"about_ca_topic_score_gemma":0.000216267,"domain_scores_codex":[0.9998558,0.00003644512,0.00001301927,0.00001687551,0.00003224704,0.00004555931],"domain_scores_gemma":[0.9998928,0.00001720818,0.00004290825,0.00001309904,0.00001256571,0.00002146324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001348758,0.00001906568,0.0001575994,0.00001657435,0.000001997246,0.00002336642,0.000004620733,0.00002348536,0.9992552,0.00001702978,0.000002499645,0.0003435721],"study_design_scores_gemma":[0.00001906276,0.0008074233,0.004353633,0.000003504014,0.00001221584,0.0001718976,0.00001560154,0.0002881139,0.9940148,0.00001779828,0.0002933963,0.00000257509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988625,0.0004566629,0.0004287442,0.00002092683,0.000004067854,0.00000548466,0.00002506647,0.000009191036,0.0001874237],"genre_scores_gemma":[0.9988887,0.0002289603,0.0005316739,0.00002237073,0.000005338154,0.000005964417,0.00006763246,0.000005026265,0.0002443586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004949001,"threshold_uncertainty_score":0.001655579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007110488823836185,"score_gpt":0.2392582289555666,"score_spread":0.2321477401317304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}