{"id":"W2128459026","doi":"10.4049/jimmunol.165.10.5750","title":"Modulation of Innate and Acquired Immune Responses by <i>Escherichia coli</i> Heat-Labile Toxin: Distinct Pro- and Anti-Inflammatory Effects of the Nontoxic AB Complex and the Enzyme Activity","year":2000,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College; Institute of Infection and Immunity","funders":"","keywords":"In vivo; Pertussis toxin; Immune system; Innate immune system; Cytokine; Escherichia coli; Bordetella pertussis; Enzyme; In vitro; Biology; Secretion; Adjuvant; Tumor necrosis factor alpha; Microbiology; Chemistry; Signal transduction; Biochemistry; Immunology; Bacteria; G protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009869571,0.0001411699,0.000358333,0.00002506823,0.0001914323,0.00001120553,0.0002506595,0.00009132751,0.000005083161],"category_scores_gemma":[0.0003703712,0.00007218051,0.00006126629,0.00009436557,0.00162458,0.00001297618,0.0002428434,0.0001781161,1.058114e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001112023,"about_ca_system_score_gemma":0.00006937947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006040734,"about_ca_topic_score_gemma":0.00001510471,"domain_scores_codex":[0.9980963,0.001148871,0.00032559,0.0001114104,0.0001427096,0.0001750427],"domain_scores_gemma":[0.9988374,0.0004285879,0.0002989298,0.0002821227,0.000127928,0.00002503879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003635416,0.00005890579,0.001590741,0.00005940079,0.0002796713,8.606335e-7,0.0003638061,0.00001013141,0.9914722,0.00001206305,0.00008117306,0.002435606],"study_design_scores_gemma":[0.002318472,0.0005892588,0.4768228,0.00004576766,0.00006401342,0.00006056562,0.00008710993,0.0001656986,0.5192198,0.0000449717,0.0005066583,0.0000748919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810373,0.0175429,0.00002916192,0.0009134398,0.00004212319,0.0003753591,0.000009291207,0.00000203361,0.00004841196],"genre_scores_gemma":[0.9930217,0.006761472,0.00003071708,0.00005137608,0.0000268077,0.000008175509,9.287727e-7,0.00001075418,0.000088013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.475232,"threshold_uncertainty_score":0.5985834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007110488823836185,"score_gpt":0.2392582289555666,"score_spread":0.2321477401317304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}