{"id":"W2128517811","doi":"10.1177/1073858410390378","title":"Small Changes, Big Impact","year":2011,"lang":"en","type":"review","venue":"The Neuroscientist","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; SUMO protein; Phenotype; Proteolysis; Palmitoylation; Huntingtin; Ubiquitin; Biology; Cell biology; Kinase; Phosphatase; Polyglutamine tract; Chemistry; Genetics; Enzyme; Biochemistry; Gene; Mutant; Cysteine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002709035,0.0008464208,0.00112353,0.0003210421,0.0006112779,0.0003785623,0.002658858,0.0001378208,0.0001678306],"category_scores_gemma":[0.001031094,0.0004885491,0.0008173008,0.001371643,0.0007523604,0.0000326461,0.0007623605,0.0006023296,0.0009646526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000691003,"about_ca_system_score_gemma":0.0003554248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003048591,"about_ca_topic_score_gemma":0.00004073105,"domain_scores_codex":[0.9950634,0.001518228,0.0004873672,0.001567871,0.0004668977,0.0008962204],"domain_scores_gemma":[0.9967082,0.0005034682,0.0005350609,0.001879382,0.00004222597,0.0003316912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006891459,0.0001775683,0.000001297664,0.001252457,0.00001015763,0.0001040886,0.00003772712,0.000001163063,0.003706219,0.000549601,0.002715334,0.9914375],"study_design_scores_gemma":[0.00009190048,0.0001356349,0.00001981964,0.0004946084,0.0003279481,0.0002765121,7.950005e-7,0.000003345364,0.005198073,0.000056238,0.9929287,0.0004663963],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003858096,0.988398,0.00002386573,0.00003852338,0.006171213,0.001636741,0.0007950776,0.0001944291,0.002356324],"genre_scores_gemma":[0.0001954325,0.9901508,0.000007489731,0.0008185558,0.0004739257,0.0002191578,0.00001764231,0.0001706132,0.007946344],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9909711,"threshold_uncertainty_score":0.9998132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2920930542564718,"score_gpt":0.3589110694795457,"score_spread":0.06681801522307396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}