{"id":"W2128517811","doi":"10.1177/1073858410390378","title":"Small Changes, Big Impact","year":2011,"lang":"en","type":"review","venue":"The Neuroscientist","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; SUMO protein; Phenotype; Proteolysis; Palmitoylation; Huntingtin; Ubiquitin; Biology; Cell biology; Kinase; Phosphatase; Polyglutamine tract; Chemistry; Genetics; Enzyme; Biochemistry; Gene; Mutant; Cysteine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005912367,0.0009894095,0.0009780886,0.001085214,0.0003760242,0.001413736,0.001099811,0.001733511,0.03425066],"category_scores_gemma":[0.00132589,0.000285723,0.0005110511,0.001023171,0.0008928142,0.002100922,0.001314229,0.00220668,0.02284372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005239487,"about_ca_system_score_gemma":0.0006473005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005605622,"about_ca_topic_score_gemma":0.001173498,"domain_scores_codex":[0.999697,0.00004821013,0.00003404964,0.00004914627,0.0001418264,0.00002978886],"domain_scores_gemma":[0.9995193,0.0002123279,0.00004885154,0.00004691815,0.00009461254,0.00007790502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000829222,0.00005896136,0.00008829861,0.003813743,0.00004203399,0.0003668645,0.00004274731,0.0001093724,0.002784731,0.00758944,0.09897188,0.8860491],"study_design_scores_gemma":[0.00001182945,0.00003502512,0.0002232267,0.0004166024,0.0000171781,0.001131083,0.00002074984,0.00001883611,0.0004555329,0.002165068,0.9954986,0.000006272733],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004990486,0.9423445,0.00197309,0.003091021,0.006912942,0.00006287384,0.000219999,0.0001997686,0.04469669],"genre_scores_gemma":[0.006227029,0.9230703,0.00288944,0.005158326,0.004559613,0.00008871873,0.0004839885,0.00007736186,0.0574453],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.03425066,"threshold_uncertainty_score":0.1145799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2920930542564718,"score_gpt":0.3589110694795457,"score_spread":0.06681801522307396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}