{"id":"W2128523101","doi":"10.1194/jlr.m700481-jlr200","title":"ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo","year":2008,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; Child and Family Research Institute; McGill University; University of British Columbia","funders":"","keywords":"ABCG1; Liver X receptor; Cholesterol; Apolipoprotein E; ABCA1; Endocrinology; Biology; Internal medicine; Chemistry; Transporter; Biochemistry; Nuclear receptor; Medicine; Disease; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002138072,0.0006655175,0.0005964104,0.0004938436,0.0002887036,0.0006208515,0.0003988823,0.0006616691,0.002737602],"category_scores_gemma":[0.00029306,0.0002804275,0.0003330634,0.0002809954,0.0008394435,0.0004708305,0.0002721663,0.001327468,0.0008574426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005517579,"about_ca_system_score_gemma":0.0005118755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002192284,"about_ca_topic_score_gemma":0.002534377,"domain_scores_codex":[0.9995599,0.0001013992,0.000033204,0.00008643319,0.00008746813,0.0001314516],"domain_scores_gemma":[0.9996226,0.0000842535,0.00007165212,0.00007091372,0.00004036952,0.0001102422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008783808,0.0001313563,0.0002228047,0.000042332,0.00001878772,0.0001707449,0.00003062973,0.00004950462,0.9960368,0.000250358,0.0001979462,0.001970306],"study_design_scores_gemma":[0.0001231064,0.0007149243,0.005836466,0.00001203734,0.00008325693,0.000499083,0.00009483191,0.0008741723,0.9865514,0.0003514359,0.004844612,0.00001461136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928914,0.001922514,0.00144118,0.0006824748,0.0001500415,0.00002978319,0.0004748341,0.0001776224,0.002230081],"genre_scores_gemma":[0.9876927,0.002040859,0.0009995514,0.0003222117,0.00004702417,0.00009460685,0.0008320544,0.0001407774,0.007830326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002737602,"threshold_uncertainty_score":0.009158194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06550909015679268,"score_gpt":0.3491889824732547,"score_spread":0.2836798923164621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}