{"id":"W2128523101","doi":"10.1194/jlr.m700481-jlr200","title":"ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo","year":2008,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; Child and Family Research Institute; McGill University; University of British Columbia","funders":"","keywords":"ABCG1; Liver X receptor; Cholesterol; Apolipoprotein E; ABCA1; Endocrinology; Biology; Internal medicine; Chemistry; Transporter; Biochemistry; Nuclear receptor; Medicine; Disease; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.007422401,0.0003978181,0.001103705,0.001230843,0.0003780705,0.0001389599,0.0009446188,0.0002781602,0.000345883],"category_scores_gemma":[0.003646933,0.0001821644,0.0003896608,0.001173788,0.0009285193,0.0004888275,0.0002298451,0.002671362,0.00006566742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001468526,"about_ca_system_score_gemma":0.001118513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003546271,"about_ca_topic_score_gemma":0.0002053057,"domain_scores_codex":[0.9926183,0.001816926,0.001304981,0.0004651592,0.002711424,0.001083236],"domain_scores_gemma":[0.9964783,0.000951744,0.0004974311,0.0007779617,0.0007551648,0.0005393907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003818257,0.0007955229,0.003443928,0.0002950326,0.0001602753,0.0004996542,0.003567773,0.00001246165,0.9724674,0.00007451664,0.001666702,0.01319849],"study_design_scores_gemma":[0.006985122,0.001627572,0.09561951,0.001458152,0.0000634519,0.002510047,0.001092844,0.00004944754,0.7466547,0.0001592053,0.1434147,0.0003652744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760761,0.000936591,0.00001021377,0.01997088,0.0005934098,0.001970737,0.00003473586,0.00002658401,0.0003807264],"genre_scores_gemma":[0.9829963,0.000576759,0.0003356315,0.000841169,0.004162178,0.0001566068,8.641383e-7,0.00006630818,0.01086423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2258127,"threshold_uncertainty_score":0.9996295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06550909015679268,"score_gpt":0.3491889824732547,"score_spread":0.2836798923164621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}