{"id":"W2128557107","doi":"10.1124/dmd.111.042564","title":"Inhibition of Heme Oxygenase-1 Partially Reverses the Arsenite-Mediated Decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 Catalytic Activity in Isolated Rat Hepatocytes","year":2011,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Aryl hydrocarbon receptor; Heme oxygenase; CYP1A2; Cytochrome P450; Heme; Enzyme inducer; Inducer; Chemistry; Enzyme; Biochemistry; Messenger RNA; Cytochrome; Sodium arsenite; Molecular biology; Biology; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002469657,0.0005779683,0.0007379892,0.0003521693,0.000219683,0.0003876573,0.0003488772,0.0002970701,0.001472832],"category_scores_gemma":[0.0002922941,0.000293988,0.000397344,0.0002372269,0.0004770897,0.0003020355,0.000189674,0.0009951025,0.000334321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003548317,"about_ca_system_score_gemma":0.000576317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001914685,"about_ca_topic_score_gemma":0.003448001,"domain_scores_codex":[0.9998257,0.00003759001,0.00001716931,0.00002537597,0.00003943215,0.00005484514],"domain_scores_gemma":[0.9996668,0.00007616879,0.00008192639,0.00006281341,0.00003955351,0.00007274609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001819724,0.00016808,0.0003978969,0.0000572901,0.00004261306,0.00009857683,0.00003724104,0.0001990116,0.9936563,0.0001406944,0.0001695694,0.003212988],"study_design_scores_gemma":[0.00005437753,0.0006401397,0.001848526,0.000002382674,0.00003279077,0.00009370824,0.00001934417,0.0005544387,0.9960858,0.00003602783,0.0006269371,0.0000055789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995028,0.001237186,0.001958303,0.000212016,0.00008945267,0.00002192241,0.000223194,0.0003385629,0.0008913958],"genre_scores_gemma":[0.9962925,0.0004772804,0.0008326363,0.00004250438,0.00002659168,0.00001638483,0.0003274739,0.00003533957,0.001949244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001914685,"threshold_uncertainty_score":0.004927099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009078824764222311,"score_gpt":0.209447729714955,"score_spread":0.2003689049507327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}