{"id":"W2128557107","doi":"10.1124/dmd.111.042564","title":"Inhibition of Heme Oxygenase-1 Partially Reverses the Arsenite-Mediated Decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 Catalytic Activity in Isolated Rat Hepatocytes","year":2011,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Aryl hydrocarbon receptor; Heme oxygenase; CYP1A2; Cytochrome P450; Heme; Enzyme inducer; Inducer; Chemistry; Enzyme; Biochemistry; Messenger RNA; Cytochrome; Sodium arsenite; Molecular biology; Biology; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002752169,0.0001911239,0.0002761725,0.00008237227,0.0000683319,0.00001047859,0.00007042207,0.0001257088,0.00001957237],"category_scores_gemma":[0.00009811565,0.0001531642,0.00007604387,0.0001540824,0.0002025181,0.00002761685,0.00009946302,0.00008115394,0.000002061242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007572178,"about_ca_system_score_gemma":0.00004826365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000610268,"about_ca_topic_score_gemma":0.0005711174,"domain_scores_codex":[0.9988569,0.0001738747,0.0003234825,0.0003094519,0.0001318394,0.0002044319],"domain_scores_gemma":[0.9992947,0.00003439168,0.0001925608,0.0002660677,0.00008075329,0.000131509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007956651,0.0001749783,0.003776256,0.0000608243,0.00003730703,0.000007798733,0.0005860735,0.000003352062,0.9938296,0.0001148477,0.00007788642,0.0005353989],"study_design_scores_gemma":[0.001139946,0.00007977184,0.05970996,0.00004094031,0.0001017021,0.00001320122,0.0002127932,0.0003003583,0.9379095,0.00009905891,0.0002110404,0.0001817039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970747,0.002088769,0.0001070155,0.00004954671,0.00005425658,0.000297102,0.0001267978,0.000008911636,0.0001929021],"genre_scores_gemma":[0.9983702,0.001071752,0.00006728365,0.0001057301,0.00004127898,0.00002946431,0.0002487499,0.00001644717,0.00004912507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0559337,"threshold_uncertainty_score":0.6245853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009078824764222311,"score_gpt":0.209447729714955,"score_spread":0.2003689049507327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}