{"id":"W2128573741","doi":"10.1093/hmg/ddq452","title":"The Machado–Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Wellcome Trust; University of Pennsylvania; National Ataxia Foundation","keywords":"Parkin; Biology; Ubiquitin ligase; Ubiquitin; Mutant; Genetics; Wild type; Machado–Joseph disease; Parkinsonism; PINK1; Deubiquitinating enzyme; Cell biology; Autophagy; Parkinson's disease; Disease; Spinocerebellar ataxia; Gene; Internal medicine; Mitophagy; Medicine; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000220108,0.0002054374,0.0001621053,0.00004708236,0.0003971316,0.00009486941,0.0003402851,0.00006146824,0.00003555752],"category_scores_gemma":[0.0009818528,0.0001723157,0.00008837682,0.0001631538,0.0005918033,0.00003669157,0.0001937194,0.0001719318,0.000002721601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001768042,"about_ca_system_score_gemma":0.00007837995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005096352,"about_ca_topic_score_gemma":0.00009685197,"domain_scores_codex":[0.9981224,0.0002566515,0.0003543138,0.0004848675,0.0004592067,0.0003225378],"domain_scores_gemma":[0.9986038,0.000180958,0.0002161272,0.0006540844,0.0001585625,0.0001865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000172754,0.0001043317,0.004813998,0.00001706305,0.000007211928,0.00001000632,0.0001352303,0.00001594248,0.9897246,0.004206563,0.00001396188,0.000933791],"study_design_scores_gemma":[0.0002665163,0.00007832448,0.156532,0.000006831829,0.00004274911,0.000002100371,0.000018124,0.0006512057,0.8303736,0.01171485,0.0001635627,0.0001501692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998661,0.0002171987,0.00007430192,0.0001590351,0.0001224893,0.0004775675,0.00009430099,0.00003720318,0.0001568615],"genre_scores_gemma":[0.9995723,0.00006264388,0.00009398532,0.0001453317,0.00002190669,0.00003048572,0.00001476843,0.00003452787,0.00002402687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.159351,"threshold_uncertainty_score":0.7026829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02085936249382663,"score_gpt":0.2604591659458783,"score_spread":0.2395998034520517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}