{"id":"W2128579789","doi":"10.1126/science.1213256","title":"A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield","year":2011,"lang":"en","type":"article","venue":"Science","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":704,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; Engineering and Physical Sciences Research Council; National Institute of Allergy and Infectious Diseases","keywords":"Glycan; Antibody; Neutralization; Immunoglobulin Fab Fragments; Chemistry; Binding site; Neutralizing antibody; Virology; Glycoprotein; Biology; Immunoglobulin light chain; Biochemistry; Complementarity determining region; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001831854,0.0003357111,0.000208327,0.0002266,0.0001078807,0.0002702119,0.0002213119,0.0003231773,0.0006258073],"category_scores_gemma":[0.0001012529,0.0001250593,0.0001703436,0.0001067136,0.000232234,0.0001448714,0.0002851311,0.0005145886,0.000273379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002289009,"about_ca_system_score_gemma":0.0001612251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003683387,"about_ca_topic_score_gemma":0.0004862348,"domain_scores_codex":[0.9998937,0.00001300167,0.000003179956,0.00001637386,0.00003725267,0.00003640482],"domain_scores_gemma":[0.9999608,0.000006601055,0.00000596977,0.000004574083,0.000004935849,0.00001718599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003877423,0.00003199382,0.0004679218,0.00002378579,0.00000583565,0.00005959974,0.0000107235,0.0001364999,0.9933202,0.0001719888,0.00005137192,0.005681334],"study_design_scores_gemma":[0.00006299073,0.001522772,0.01170782,0.00001460703,0.00002643062,0.001914442,0.00002997633,0.001331187,0.9775066,0.0002848741,0.005591959,0.000006241384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888282,0.00216883,0.004443414,0.00008279114,0.00001332823,0.000038125,0.00006950986,0.00007928577,0.004276575],"genre_scores_gemma":[0.9964327,0.0004819717,0.001897845,0.00009019762,0.00001067105,0.000007264844,0.000107969,0.000005470973,0.0009659661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006258073,"threshold_uncertainty_score":0.002093554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03504596051319639,"score_gpt":0.2852055924159718,"score_spread":0.2501596319027755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}