{"id":"W2128590337","doi":"10.2337/diabetes.54.12.3410","title":"Inhibition of Preproinsulin Gene Expression by Leptin Induction of Suppressor of Cytokine Signaling 3 in Pancreatic β-Cells","year":2005,"lang":"en","type":"article","venue":"Diabetes","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Deutscher Akademischer Austauschdienst; Michael Smith Health Research BC","keywords":"SOCS3; Janus kinase; STAT protein; STAT3; Signal transduction; Biology; JAK-STAT signaling pathway; Pancreatic islets; Leptin receptor; Leptin; stat; Endocrinology; Internal medicine; Janus kinase 2; Cell biology; Insulin; Tyrosine kinase; Islet; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000204816,0.00008107323,0.0002148624,0.0001181187,0.00001867062,0.000004377584,0.00007567623,0.00006330338,0.00006610706],"category_scores_gemma":[0.0001371728,0.00007699034,0.0000438565,0.0002095323,0.00007767328,0.0002040917,0.00003342424,0.00005986126,0.000003420579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001414724,"about_ca_system_score_gemma":0.00001162412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001528507,"about_ca_topic_score_gemma":8.429847e-7,"domain_scores_codex":[0.9989482,0.00009995006,0.0004138336,0.0002027695,0.0002150237,0.0001202309],"domain_scores_gemma":[0.9993337,0.0001319761,0.0002989599,0.000168117,0.00004355596,0.00002370787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002370734,0.0002148981,0.008104564,0.00008300561,0.000001307737,1.253386e-7,0.0002283662,0.001706438,0.9891351,0.00001536953,0.00005105829,0.0004359899],"study_design_scores_gemma":[0.0004308573,0.00007482025,0.00350152,0.0001933623,0.00000577633,1.153726e-7,0.0000222203,0.0007219177,0.994836,0.000116022,0.00003227093,0.00006506155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994693,0.0000616636,0.00004992999,0.0000394899,0.00002483914,0.0001793919,0.00004248832,0.00001177576,0.0001210683],"genre_scores_gemma":[0.9989852,0.00002442072,0.0008776893,0.00001667714,0.00003075012,0.000006874118,0.00001198656,0.000008135282,0.00003830688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005700885,"threshold_uncertainty_score":0.3139575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01566928875902254,"score_gpt":0.2325957368755726,"score_spread":0.21692644811655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}