{"id":"W2128639169","doi":"10.1093/annonc/12.suppl_1.s43","title":"Pharmacologic insights into the future of trastuzumab","year":2001,"lang":"en","type":"review","venue":"Annals of Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Regional Cancer Foundation; Hamilton Regional Laboratory Medicine Program; McGill University","funders":"","keywords":"Trastuzumab; Medicine; Oncology; Clinical trial; Regimen; Breast cancer; Pharmacokinetics; Metastatic breast cancer; Pharmacodynamics; Pharmacology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009392479,0.000337482,0.002915182,0.0003437457,0.00005740291,0.000003871006,0.0006854648,0.0007789587,0.001080555],"category_scores_gemma":[0.0001571206,0.0001852557,0.0006998946,0.0008872357,0.0005605309,0.00002890762,0.0001815228,0.001216071,0.00007778567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000218308,"about_ca_system_score_gemma":0.002744631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008444369,"about_ca_topic_score_gemma":0.00005601467,"domain_scores_codex":[0.9968385,0.0008073493,0.001031874,0.00038442,0.0005042538,0.0004335887],"domain_scores_gemma":[0.9972771,0.0007749642,0.0006780868,0.000612554,0.0004856832,0.0001716095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008728527,0.00041264,0.000005079907,0.01080034,0.0004758,0.0001875371,0.0004582237,2.216679e-7,0.000009589568,0.0001785123,0.05541376,0.931971],"study_design_scores_gemma":[0.0005007039,0.003845359,0.00001314503,0.002553668,0.0006305848,0.0001558729,0.0001435831,0.000001187554,0.0000620916,0.0002121105,0.9917501,0.0001316612],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001751213,0.9743127,0.000002298098,0.003534609,0.0006475697,0.001389327,0.00001254691,0.00001853451,0.01990734],"genre_scores_gemma":[0.0003002578,0.9960494,0.00007670862,0.001002086,0.0014227,0.000199348,0.00004026418,0.00004579626,0.0008634476],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9363363,"threshold_uncertainty_score":0.9998326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3103481636436475,"score_gpt":0.5674658620510857,"score_spread":0.2571176984074382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}