{"id":"W2128666169","doi":"10.1186/1471-2202-13-84","title":"New highly sensitive rodent and human tests for soluble amyloid precursor protein alpha quantification: preclinical and clinical applications in Alzheimer’s disease","year":2012,"lang":"en","type":"article","venue":"BMC Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Institut National de la Santé et de la Recherche Médicale","keywords":"Genetically modified mouse; Amyloid precursor protein; In vivo; Neuroprotection; Biomarker; Transgene; Amyloid (mycology); Cerebrospinal fluid; Endogeny; Alzheimer's disease; Chemistry; Amyloid beta; Neurotrophin; Molecular biology; Cell biology; Biology; Neuroscience; Biochemistry; Medicine; Disease; Pathology; Peptide; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003910083,0.002391216,0.0009087502,0.001274825,0.0002330981,0.0008446066,0.001127258,0.002030006,0.002193816],"category_scores_gemma":[0.002529114,0.0005983667,0.0008216841,0.0006255416,0.001104318,0.00098192,0.0006869599,0.002535833,0.001309311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005330564,"about_ca_system_score_gemma":0.0005479489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002674481,"about_ca_topic_score_gemma":0.0004445486,"domain_scores_codex":[0.9975962,0.0007983588,0.0001402085,0.0004835431,0.0008129172,0.0001687686],"domain_scores_gemma":[0.9978484,0.0007199685,0.0004720908,0.0001426466,0.0005827648,0.0002341367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004469207,0.000269053,0.000904016,0.0004693924,0.00004473486,0.0001177912,0.00006362498,0.0002217978,0.9697674,0.0004488137,0.0008191086,0.02642732],"study_design_scores_gemma":[0.0001515182,0.005199365,0.008412283,0.0001713786,0.0002024585,0.00295247,0.00008611299,0.002710446,0.9622352,0.00115797,0.0166243,0.00009638083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2403878,0.06008665,0.6815287,0.001487892,0.001107805,0.001942244,0.001886336,0.003743501,0.007829093],"genre_scores_gemma":[0.482163,0.02101295,0.4757908,0.002132382,0.0005575297,0.003691985,0.002880377,0.0003458939,0.01142496],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003910083,"threshold_uncertainty_score":0.0206787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1745612733468897,"score_gpt":0.4446190212250207,"score_spread":0.270057747878131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}