{"id":"W2128733938","doi":"10.1146/annurev.nutr.26.061505.111214","title":"Variations on a Gene: Rare and Common Variants in <i>ABCA1</i> and Their Impact on HDL Cholesterol Levels and Atherosclerosis","year":2006,"lang":"en","type":"review","venue":"Annual Review of Nutrition","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"","keywords":"ABCA1; Tangier disease; Cholesterol; Biology; Reverse cholesterol transport; High-density lipoprotein; Apolipoprotein B; Population; Lipoprotein; Endocrinology; Phenotype; Genetics; Internal medicine; Gene; Medicine; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005412007,0.0005572714,0.002791169,0.0002920247,0.00005766823,0.00003285486,0.00008506493,0.0003072229,0.000009909854],"category_scores_gemma":[0.00009389765,0.00035883,0.0002981756,0.0003386259,0.00008215902,0.0001488342,0.00005499128,0.000454349,0.000004161064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006542241,"about_ca_system_score_gemma":0.00006499402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001026519,"about_ca_topic_score_gemma":0.0000120451,"domain_scores_codex":[0.9977357,0.0003635559,0.0009157254,0.0005149101,0.0002224706,0.0002475738],"domain_scores_gemma":[0.9986004,0.0002865286,0.0004557571,0.0004071518,0.00009118381,0.0001590132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003095911,0.0007453208,0.0001045382,0.1060407,0.00009033399,0.000004133068,0.0001138566,3.941632e-8,0.0000158742,0.00005767697,0.0008413669,0.8919552],"study_design_scores_gemma":[0.002323507,0.000769591,0.04808982,0.3949105,0.0009991733,0.0002064162,0.00001571306,0.000002509596,0.000006775801,0.00007098179,0.5522595,0.0003454309],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004452924,0.9908129,0.000005332884,0.0003050671,0.00007220468,0.002248958,0.00196118,0.00001814526,0.0001232903],"genre_scores_gemma":[0.002843153,0.9950586,0.00007140441,0.0009767869,0.0002639489,0.0001932528,0.0005107532,0.00005222192,0.00002986287],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8916098,"threshold_uncertainty_score":0.9998864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03850205344818078,"score_gpt":0.3431730452089102,"score_spread":0.3046709917607294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}