{"id":"W2128743925","doi":"10.1128/iai.01104-10","title":"Antibiotic Treatment Alters the Colonic Mucus Layer and Predisposes the Host to Exacerbated <i>Citrobacter rodentium</i> -Induced Colitis","year":2011,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":376,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Citrobacter rodentium; Mucus; Microbiology; Biology; Colitis; Antibiotics; Metronidazole; Goblet cell; Intestinal mucosa; Immunology; Medicine; Epithelium; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001819709,0.0005288807,0.0005042992,0.0004724993,0.0001890345,0.0003209999,0.0001826137,0.0005674493,0.001296161],"category_scores_gemma":[0.0002993765,0.0002955516,0.0003219942,0.0002016196,0.0002918738,0.0002574287,0.0002182618,0.0007821438,0.0002561666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002845611,"about_ca_system_score_gemma":0.000205327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005961561,"about_ca_topic_score_gemma":0.0007798177,"domain_scores_codex":[0.999687,0.0000764231,0.00003579263,0.00006768542,0.00004434742,0.00008885346],"domain_scores_gemma":[0.9996412,0.00003020199,0.0001590247,0.00002799244,0.00001829743,0.0001232946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008786733,0.0001523309,0.002170925,0.00004320424,0.00001013278,0.0002391616,0.00001560493,0.00003444601,0.995281,0.00001789652,0.00003852829,0.001117974],"study_design_scores_gemma":[0.0001761286,0.01691715,0.2386206,0.00007767737,0.0001206847,0.005688334,0.0003090389,0.00124754,0.7335806,0.000129728,0.003082208,0.00005019721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997838,0.0009742113,0.0003753498,0.0001096021,0.00001883143,0.00002396533,0.0001079004,0.00004378972,0.0005083445],"genre_scores_gemma":[0.9982675,0.000530398,0.0005345136,0.00009257494,0.000009258771,0.00001900197,0.0001525712,0.00001151605,0.0003825998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001296161,"threshold_uncertainty_score":0.004336119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03063713451176739,"score_gpt":0.2627107348169551,"score_spread":0.2320736003051877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}