{"id":"W2128743925","doi":"10.1128/iai.01104-10","title":"Antibiotic Treatment Alters the Colonic Mucus Layer and Predisposes the Host to Exacerbated <i>Citrobacter rodentium</i> -Induced Colitis","year":2011,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":376,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Citrobacter rodentium; Mucus; Microbiology; Biology; Colitis; Antibiotics; Metronidazole; Goblet cell; Intestinal mucosa; Immunology; Medicine; Epithelium; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646285,0.0001174194,0.00009318906,0.00002264778,0.0003626351,0.00004015503,0.00006129556,0.00007759238,0.00001729012],"category_scores_gemma":[0.00002010308,0.00006952835,0.00003524053,0.00007290391,0.00007609971,0.000005768389,0.00007783476,0.00008818071,0.000009309013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002222357,"about_ca_system_score_gemma":0.00003785669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005541374,"about_ca_topic_score_gemma":0.00286061,"domain_scores_codex":[0.9993404,0.0001850829,0.0001114141,0.000157989,0.00003152248,0.0001735759],"domain_scores_gemma":[0.9995853,0.00001562753,0.00004530541,0.0002462522,0.00004408299,0.00006348428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001377343,0.000136073,0.04486533,0.00001365524,0.00008096128,7.973478e-7,0.001124192,4.594955e-7,0.9513735,0.00003106617,0.0004478973,0.00178832],"study_design_scores_gemma":[0.0004067356,0.0007835928,0.8611442,0.000009159913,0.0000340756,0.00004358371,0.0001105813,0.000004257055,0.1273682,0.000004099856,0.01000165,0.00008988573],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985323,0.0002113855,0.00002282663,0.0002733732,0.0001860086,0.0003840168,0.00001126061,0.0000167705,0.0003620441],"genre_scores_gemma":[0.9980148,0.0009832409,0.00001047587,0.0006812273,0.00004602452,0.00001325881,0.00001279186,0.00001152786,0.0002266277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8240053,"threshold_uncertainty_score":0.8376938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03063713451176739,"score_gpt":0.2627107348169551,"score_spread":0.2320736003051877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}