{"id":"W2128751668","doi":"10.1007/s00125-005-1939-4","title":"Glucose-induced Akt1 activation mediates fibronectin synthesis in endothelial cells","year":2005,"lang":"en","type":"article","venue":"Diabetologia","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Lawson Health Research Institute; Canadian Diabetes Association","keywords":"Protein kinase B; Fibronectin; AKT1; Cell biology; Protein kinase A; Biology; Molecular biology; Chemistry; Kinase; Signal transduction; Extracellular matrix","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001341703,0.0003532887,0.0001768685,0.0002683019,0.0002234909,0.0004002858,0.0002049703,0.0002018865,0.001729748],"category_scores_gemma":[0.00008531257,0.0001731387,0.0002524405,0.0002134052,0.0001584743,0.0002264264,0.0002157084,0.0007355564,0.0004744362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005773272,"about_ca_system_score_gemma":0.0002394326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002557859,"about_ca_topic_score_gemma":0.003210156,"domain_scores_codex":[0.9998846,0.00001862337,0.000008480387,0.00001725204,0.00001808345,0.00005294049],"domain_scores_gemma":[0.9999405,0.000009240121,0.000009606492,0.000008787873,0.000007473243,0.00002426712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00070312,0.00009145535,0.0003495229,0.00007447453,0.00001116046,0.0001180004,0.00002120802,0.00009286545,0.9955488,0.0004265735,0.0003026866,0.002260024],"study_design_scores_gemma":[0.00008021908,0.0002647367,0.02194753,0.00001237781,0.00002781672,0.0001891254,0.000085132,0.001429375,0.9716959,0.0001913484,0.004067322,0.000009065396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893737,0.003020981,0.001482757,0.0003619294,0.0001244084,0.00002496685,0.001120535,0.00008742872,0.004403101],"genre_scores_gemma":[0.9926413,0.001366824,0.0008635515,0.0001394505,0.00002550641,0.00003731727,0.001442908,0.00001350685,0.003469642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002557859,"threshold_uncertainty_score":0.005786598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119363944948367,"score_gpt":0.2475239893796749,"score_spread":0.2355875948848382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}