{"id":"W2128768874","doi":"10.1093/nar/gkn728","title":"IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels","year":2008,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":220,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"Servier; University of Oxford; British Pharmacological Society; Incyte; GlaxoSmithKline","keywords":"Biology; G protein-coupled receptor; Clinical pharmacology; Gene; Receptor; Systems pharmacology; Drug discovery; Computational biology; Pharmacology; Drug; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001715397,0.003160801,0.005291371,0.006199203,0.0009096508,0.005912389,0.006266983,0.002556591,0.06094049],"category_scores_gemma":[0.003658233,0.00109821,0.001732033,0.008527628,0.0005186865,0.003259557,0.003211655,0.00226753,0.111813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009365465,"about_ca_system_score_gemma":0.003625864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002087194,"about_ca_topic_score_gemma":0.001581172,"domain_scores_codex":[0.9985572,0.0002277744,0.000323249,0.0003388221,0.0003439029,0.0002090682],"domain_scores_gemma":[0.9981918,0.0003672515,0.0003476613,0.0003195883,0.0003509974,0.0004226111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001762068,0.0001681345,0.001628993,0.01212083,0.0003616909,0.0006187374,0.0001891603,0.001631525,0.02437265,0.01100182,0.870572,0.07557228],"study_design_scores_gemma":[0.0002743522,0.00007498435,0.001755394,0.0006566328,0.0001755665,0.0005774655,0.00006153866,0.001297992,0.00477769,0.004201165,0.9860674,0.00007987822],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.002497179,0.01737656,0.0180055,0.000655985,0.0005315118,0.0002918712,0.9142748,0.02779156,0.01857511],"genre_scores_gemma":[0.003709158,0.005518132,0.009271185,0.000307102,0.00009128671,0.0002708259,0.9769028,0.0014225,0.002507058],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.06094049,"threshold_uncertainty_score":0.2038662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04772066875641533,"score_gpt":0.3184688695125029,"score_spread":0.2707482007560876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}