{"id":"W2128806688","doi":"10.2741/3109","title":"Self-assembly of amyloid-forming peptides by molecular dynamics simulations","year":2008,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre National de la Recherche Scientifique; Natural Sciences and Engineering Research Council of Canada; Fudan University; National Natural Science Foundation of China","keywords":"Molecular dynamics; Amyloid fibril; Random coil; Dimer; Amyloid (mycology); Protein aggregation; Biophysics; Peptide; Chemistry; Fibril; Biological system; Nanotechnology; Chemical physics; Computer science; Amyloid β; Materials science; Biology; Protein secondary structure; Computational chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000110255,0.0003217269,0.001123002,0.0005340948,0.000105704,0.00001740591,0.0003387273,0.0001933911,0.000003929486],"category_scores_gemma":[0.0001114234,0.0002603495,0.0003166112,0.00120693,0.0002972757,0.0001421719,0.00009263062,0.000264007,0.000008744099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007889235,"about_ca_system_score_gemma":0.00150742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003479748,"about_ca_topic_score_gemma":0.000003228407,"domain_scores_codex":[0.9978459,0.00007932115,0.0005067445,0.0004993308,0.0005769609,0.0004917216],"domain_scores_gemma":[0.9988663,0.00006324131,0.0002357833,0.0004524991,0.00009000191,0.0002921412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000508765,0.002457366,0.01212079,0.01540916,0.005428371,0.0007835802,0.0002404172,0.00002018873,0.00001714967,0.000152628,0.005161944,0.9581575],"study_design_scores_gemma":[0.004798493,0.001650377,0.0006159018,0.03699131,0.007556939,0.0005145827,0.0004543101,0.044139,0.0004062404,0.0003370458,0.8996585,0.002877316],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004977356,0.9964789,0.001106121,0.0000162042,0.0001560845,0.0009795332,0.0002618737,0.00003560906,0.0004680089],"genre_scores_gemma":[0.003627076,0.9846678,0.01128392,0.00001617011,0.00001463916,0.00003905726,0.0002623437,0.000033037,0.00005596141],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9552802,"threshold_uncertainty_score":0.9999849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02235393580952068,"score_gpt":0.3313198959050441,"score_spread":0.3089659600955234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}