{"id":"W2128814375","doi":"10.1128/mcb.01094-10","title":"The Ubiquitin-Specific Protease USP34 Regulates Axin Stability and Wnt/β-Catenin Signaling","year":2011,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Wnt signaling pathway; Biology; Ubiquitin; Cell biology; Deubiquitinating enzyme; Proteasome; Ubiquitin ligase; Signal transduction; Transcription factor; LRP5; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006293989,0.0002889968,0.0002222024,0.0000374353,0.0003270149,0.00005151313,0.0002546582,0.0002649772,0.00006627785],"category_scores_gemma":[0.00004374974,0.0002172745,0.00009111128,0.00008906718,0.0005993844,0.000005452055,0.0002526658,0.0001583942,0.000006473072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001179674,"about_ca_system_score_gemma":0.00005754902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002793549,"about_ca_topic_score_gemma":0.00000723033,"domain_scores_codex":[0.9981987,0.0002396251,0.0003340064,0.0006643389,0.00009995171,0.0004633092],"domain_scores_gemma":[0.9992828,0.00002571344,0.0001142069,0.0003310798,0.0001045498,0.0001416027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001757426,0.00003098023,0.00275156,0.00001715903,0.00007674501,0.00001219007,0.0001659001,6.420927e-7,0.9920377,0.001594109,0.0001155471,0.003021754],"study_design_scores_gemma":[0.0004369089,0.0002470108,0.0004126613,0.00001052009,0.00002127085,0.00002090683,0.0001662938,0.000009154673,0.9831675,0.002418903,0.01277127,0.0003175611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792776,0.0159602,0.003358818,0.0001269341,0.0001481425,0.0003744653,0.000008099459,0.0000252265,0.0007204857],"genre_scores_gemma":[0.997584,0.0006575655,0.001067952,0.0001458048,0.00009967957,0.00009130149,0.00009174497,0.00003408035,0.0002279022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01830634,"threshold_uncertainty_score":0.8860195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956837944151045,"score_gpt":0.2112313260215129,"score_spread":0.1916629465800025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}