{"id":"W2128824604","doi":"10.2174/15680266113139990004","title":"A Challenge for Medicinal Chemistry by the 17&amp;#946;-hydroxysteroid Dehydrogenase Superfamily: An Integrated Biological Function and Inhibition Study","year":2013,"lang":"en","type":"review","venue":"Current Topics in Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Hydroxysteroid dehydrogenase; Enzyme; Steroid; Dehydrogenase; Dihydrotestosterone; Chemistry; Estrogen; Androgen; Prostate cancer; Receptor; Hormone; Cancer; Biochemistry; Cancer research; Biology; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000666838,0.0007222541,0.001015483,0.00003937383,0.0001598528,0.00004559494,0.000387769,0.001068418,0.00005015461],"category_scores_gemma":[0.000217054,0.0004589863,0.0002392298,0.0001660604,0.0003327381,0.00001061225,0.000175581,0.001280556,0.000004086697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001044216,"about_ca_system_score_gemma":0.0001992966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001292847,"about_ca_topic_score_gemma":0.000004389882,"domain_scores_codex":[0.9971367,0.0002278792,0.0007940393,0.001033749,0.0003061653,0.0005015083],"domain_scores_gemma":[0.9986058,0.00008287472,0.0003009474,0.000628704,0.0001072653,0.0002743711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002319551,0.001827362,0.0001678915,0.01262019,0.0005047183,0.00002265216,0.000215843,0.000001290041,0.04112028,0.000005498504,0.007057912,0.9362244],"study_design_scores_gemma":[0.002090315,0.001114491,0.000006432505,0.003210386,0.0007491919,0.0001812008,0.0005558993,0.00003352008,0.002509856,0.00005194283,0.988746,0.0007507002],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1685244,0.8293718,0.0001247898,0.00004801488,0.0002798871,0.00145149,0.00007349028,0.0000269976,0.00009919507],"genre_scores_gemma":[0.01210496,0.9789359,0.00002507872,0.00003937625,0.001660465,0.001043749,0.005769295,0.00006552182,0.0003556492],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9816881,"threshold_uncertainty_score":0.9997862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05925358796845578,"score_gpt":0.3427177011190026,"score_spread":0.2834641131505469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}