{"id":"W2128844598","doi":"10.1161/circresaha.106.147744","title":"Formation of Extracellular Matrix-Digesting Invadopodia by Primary Aortic Smooth Muscle Cells","year":2007,"lang":"en","type":"article","venue":"Circulation Research","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Invadopodia; Cortactin; Podosome; Cell biology; Extracellular matrix; CDC42; Proto-oncogene tyrosine-protein kinase Src; Vascular smooth muscle; Urokinase receptor; Chemistry; Actin; Biology; Signal transduction; Cytoskeleton; Cell; Biochemistry; Cancer cell; Endocrinology; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001791211,0.0000874992,0.00009677931,0.0001226627,0.0001270891,0.00002575945,0.0001438001,0.000156773,0.00003068304],"category_scores_gemma":[0.0001270576,0.00009399293,0.00005552067,0.0002243426,0.00006467048,0.00001894561,0.00007892775,0.0001483679,0.00002278434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004606109,"about_ca_system_score_gemma":0.00007825528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004020508,"about_ca_topic_score_gemma":0.000004629732,"domain_scores_codex":[0.9985619,0.0001092079,0.0003298111,0.0002294894,0.0004370089,0.000332536],"domain_scores_gemma":[0.999215,0.00003887089,0.0001057222,0.0002863422,0.0002596261,0.00009441916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002410326,0.0000517784,0.0003304361,0.00006972756,0.000004227363,0.000001709201,0.00004757695,0.00009217818,0.9930101,0.0001087957,0.001077708,0.005181681],"study_design_scores_gemma":[0.0002812592,0.00009544407,0.002535364,0.0000244757,0.000004160922,0.000001314791,0.00008135028,0.0009665889,0.9923153,0.0002574284,0.003331689,0.0001056528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9614097,0.001594159,0.03506098,0.00003168678,0.0000609156,0.0003812806,0.000009608714,0.00001253092,0.001439121],"genre_scores_gemma":[0.9987141,0.0000482807,0.0005553067,0.00002023635,0.0001213018,0.00001260943,0.0002241992,0.00001807828,0.0002858416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03730442,"threshold_uncertainty_score":0.383292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03307193033996139,"score_gpt":0.3180824239954789,"score_spread":0.2850104936555174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}