{"id":"W2128847469","doi":"10.1124/jpet.111.179101","title":"1α,25-Dihydroxyvitamin D3 Up-Regulates P-Glycoprotein via the Vitamin D Receptor and Not Farnesoid X Receptor in Both fxr(−/−) and fxr(+/+) Mice and Increased Renal and Brain Efflux of Digoxin in Mice In Vivo","year":2011,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Farnesoid X receptor; Calcitriol receptor; Internal medicine; Endocrinology; P-glycoprotein; Nuclear receptor; Bile acid; Chemistry; Symporter; Receptor; Multidrug resistance-associated protein 2; Transporter; Biology; Medicine; ATP-binding cassette transporter; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002563648,0.0006962904,0.0006498639,0.001185918,0.0003066577,0.0008173618,0.0004552979,0.0008686623,0.002893161],"category_scores_gemma":[0.0002331461,0.0006463354,0.0008818615,0.0003247283,0.0008503773,0.0005526559,0.0002407356,0.00184251,0.0007203614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008373652,"about_ca_system_score_gemma":0.0003828609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00225957,"about_ca_topic_score_gemma":0.003565003,"domain_scores_codex":[0.9994063,0.0000928628,0.00005134199,0.000124545,0.0001736639,0.0001512427],"domain_scores_gemma":[0.9996169,0.00004227722,0.0001325198,0.00005417145,0.00002841771,0.0001257703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003923525,0.00003433092,0.0001271703,0.00001834893,0.000009965554,0.0001105027,0.00001255546,0.00002496984,0.9986216,0.0001124152,0.000077298,0.0004584148],"study_design_scores_gemma":[0.0001202016,0.0003863633,0.004828888,0.000005720062,0.00006419985,0.0006321606,0.00006489531,0.0005102256,0.9908227,0.0001370761,0.002413379,0.00001411297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888681,0.002811763,0.003778108,0.0007784201,0.000142563,0.00004298821,0.001318997,0.0004463036,0.00181284],"genre_scores_gemma":[0.9861194,0.001264014,0.00191095,0.0002283583,0.00003906477,0.00004445381,0.0009770418,0.0001360364,0.009280644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002893161,"threshold_uncertainty_score":0.009678543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01666241484527228,"score_gpt":0.2786073177122573,"score_spread":0.261944902866985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}