{"id":"W2128852790","doi":"10.1196/annals.1332.004","title":"<i>BACE1</i> Gene Expression and Protein Degradation","year":2004,"lang":"en","type":"article","venue":"Annals of the New York Academy of Sciences","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"BACE1-AS; Amyloid precursor protein; Biochemistry of Alzheimer's disease; Proteasome; Amyloid precursor protein secretase; P3 peptide; Alpha secretase; Ubiquitin; Amyloid beta; Chemistry; Protein degradation; Amyloid (mycology); Protein precursor; Cell biology; Molecular biology; Gene; Biochemistry; Biology; Alzheimer's disease; Peptide; Medicine; Disease; Transgene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001795004,0.0003350628,0.0002695115,0.000477399,0.0003188842,0.0007147977,0.0002140334,0.0002641633,0.005277883],"category_scores_gemma":[0.0002139379,0.0001214065,0.000224732,0.0003050745,0.0004301106,0.0003168499,0.0003269709,0.0005153534,0.002553302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005743798,"about_ca_system_score_gemma":0.0001963672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008867499,"about_ca_topic_score_gemma":0.001256273,"domain_scores_codex":[0.999782,0.00002856844,0.00001627331,0.00006447158,0.00006718135,0.00004140948],"domain_scores_gemma":[0.9998715,0.00001973634,0.00003933243,0.00001774022,0.00002987284,0.00002180181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002105743,0.0000351636,0.0008722635,0.0001873809,0.0000105229,0.0004162307,0.00005391775,0.00005917218,0.9788473,0.002548026,0.003037169,0.01372226],"study_design_scores_gemma":[0.00002303069,0.0001976639,0.01818938,0.00004084014,0.00002004734,0.003155883,0.00005999283,0.000468283,0.8933846,0.001193575,0.08324958,0.00001715211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8068876,0.05985766,0.0458563,0.006402562,0.001370586,0.0002236198,0.008417258,0.002316415,0.06866799],"genre_scores_gemma":[0.8577166,0.01776402,0.02707217,0.002413659,0.0005186108,0.0002837742,0.01150113,0.0003387814,0.08239127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005277883,"threshold_uncertainty_score":0.01765627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1082723760002904,"score_gpt":0.370811771185082,"score_spread":0.2625393951847916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}