{"id":"W2128899239","doi":"10.1371/journal.pone.0007464","title":"Oncogene Mutations, Copy Number Gains and Mutant Allele Specific Imbalance (MASI) Frequently Occur Together in Tumor Cells","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":225,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; AstraZeneca; Genentech; Chiba University; MedImmune; Canary Foundation","keywords":"KRAS; Biology; Allele; Mutant; Carcinogenesis; Oncogene; Cancer research; Mutation; Wild type; Genetics; Gene; Molecular biology; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002548757,0.0002618591,0.0002567407,0.00101358,0.0001769256,0.0003010428,0.0001944201,0.0002377461,0.001608649],"category_scores_gemma":[0.0005845752,0.0001206441,0.0001509535,0.0008097031,0.000292242,0.0002416529,0.0003250919,0.0002103266,0.0004700658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002445763,"about_ca_system_score_gemma":0.0001628222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001976599,"about_ca_topic_score_gemma":0.0004702272,"domain_scores_codex":[0.9995461,0.00003568915,0.00005917089,0.0001283994,0.0001868158,0.00004374445],"domain_scores_gemma":[0.9992396,0.0001729101,0.0003505966,0.00009779014,0.00006642545,0.00007266217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004970354,0.00006929098,0.2090523,0.0001564404,0.0001315274,0.001800738,0.0001051404,0.0001630096,0.7677835,0.0002047106,0.0002027324,0.01983367],"study_design_scores_gemma":[0.00002315256,0.0005122946,0.4864099,0.00001828488,0.0001795505,0.02180145,0.0001649512,0.0009468155,0.48218,0.0004904149,0.007255867,0.00001731333],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958187,0.00102378,0.001788397,0.0000340429,0.000007468595,0.00001979994,0.0005348158,0.00006178898,0.0007113459],"genre_scores_gemma":[0.9971602,0.0003548341,0.001111923,0.00002249831,0.000008630635,0.00001867001,0.0008082741,0.000009873842,0.0005050995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001608649,"threshold_uncertainty_score":0.005381465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02133321486740111,"score_gpt":0.2439002813432822,"score_spread":0.2225670664758811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}