{"id":"W2128917661","doi":"10.1093/brain/awv132","title":"Loss of<i>PLA2G6</i>leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction","year":2015,"lang":"en","type":"article","venue":"Brain","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":191,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Motor Neurone Disease Association; Medical Research Council; Parkinson's UK; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Biology; Mitochondrion; Lipid peroxidation; Neurodegeneration; Oxidative stress; Mutation; Molecular biology; Biochemistry; Gene; Genetics; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009540273,0.0006563656,0.0002969228,0.0002531091,0.0001713516,0.0002161515,0.0001977981,0.0003938103,0.001220694],"category_scores_gemma":[0.0001207091,0.0001898285,0.0003737066,0.0001618727,0.000320731,0.0001315373,0.0002592306,0.0005413577,0.0003660027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002346185,"about_ca_system_score_gemma":0.0001078291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006357848,"about_ca_topic_score_gemma":0.0007009857,"domain_scores_codex":[0.9998549,0.00002341523,0.00002605867,0.00003866351,0.00002973983,0.00002708669],"domain_scores_gemma":[0.9998507,0.00002430033,0.00005549812,0.00001615317,0.000007818234,0.00004536524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001113832,0.00002172203,0.0002451478,0.0000177469,0.00001146088,0.0002655702,0.000008981761,0.00003871396,0.9987277,0.00003895123,0.00002978695,0.0004827525],"study_design_scores_gemma":[0.00003835003,0.0005810987,0.009246646,0.000009194996,0.00004282827,0.003557376,0.00004760206,0.0008283476,0.9837028,0.00006397907,0.001871701,0.00001011514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965984,0.0004729656,0.001623003,0.00009175736,0.00002441216,0.00002370508,0.0004502822,0.00009195201,0.0006235422],"genre_scores_gemma":[0.9962689,0.0004036227,0.001485595,0.00005251609,0.00000839591,0.00002388886,0.0005803278,0.00003495485,0.001141834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001220694,"threshold_uncertainty_score":0.004083633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03252541422001833,"score_gpt":0.2695545978804891,"score_spread":0.2370291836604708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}