{"id":"W2128989133","doi":"10.1158/0008-5472.can-08-1101","title":"BCR/ABL and Other Kinases from Chronic Myeloproliferative Disorders Stimulate Single-Strand Annealing, an Unfaithful DNA Double-Strand Break Repair","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; U.S. Department of Defense","keywords":"Biology; Cancer research; Philadelphia chromosome; Imatinib mesylate; Chronic myelogenous leukemia; Genome instability; Tyrosine kinase; Progenitor cell; ABL; DNA damage; Cell biology; Stem cell; Molecular biology; Leukemia; Imatinib; Myeloid leukemia; Signal transduction; Genetics; DNA; Chromosomal translocation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001462351,0.0004498395,0.0002016861,0.0002237206,0.0001056022,0.0001898213,0.00007486843,0.0002870951,0.001959505],"category_scores_gemma":[0.0001398052,0.0001221013,0.0002589888,0.0001369751,0.0001506955,0.0001530802,0.0002320359,0.0003533117,0.0004055825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001511448,"about_ca_system_score_gemma":0.00008478889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001102696,"about_ca_topic_score_gemma":0.0002532392,"domain_scores_codex":[0.9998296,0.00003701264,0.00001303195,0.00002870351,0.00005454475,0.00003706202],"domain_scores_gemma":[0.9999007,0.00002885987,0.00002938113,0.00001132216,0.000006814877,0.00002294218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006004041,0.00002226,0.0001455921,0.00003955502,0.000004348014,0.00003203835,0.000008525267,0.00002414591,0.9984311,0.00004851854,0.00002973798,0.001153999],"study_design_scores_gemma":[0.0000290762,0.0005459949,0.01172373,0.00001029797,0.00001529262,0.0007423452,0.0000224201,0.0004179004,0.9824616,0.00009561965,0.003931054,0.000004621701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906781,0.004922814,0.001594013,0.0001371642,0.00003150493,0.00006532836,0.0004275152,0.0000788803,0.002064721],"genre_scores_gemma":[0.9946931,0.001423988,0.00171595,0.0000657581,0.00001799056,0.0000556377,0.0006350732,0.00001085672,0.001381677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001959505,"threshold_uncertainty_score":0.0065552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1109936999606113,"score_gpt":0.3906695035664544,"score_spread":0.2796758036058432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}