{"id":"W2129055432","doi":"10.1091/mbc.e11-04-0335","title":"β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition","year":2011,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Myocardin; Serum response factor; Biology; Adherens junction; Cell biology; Transcription factor; Gene knockdown; Myofibroblast; Catenin; Beta-catenin; Transdifferentiation; Transforming growth factor; Cytoskeleton; Cadherin; Signal transduction; Wnt signaling pathway; Fibrosis; Gene; Cell; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001680025,0.0001500299,0.0001810409,0.00002416021,0.00008201862,0.000003560812,0.0001732551,0.0001842592,0.00001135713],"category_scores_gemma":[0.00002388845,0.0001007695,0.0001335765,0.00005607278,0.0006066861,0.000004269033,0.00007636714,0.00009080851,3.186583e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005791156,"about_ca_system_score_gemma":0.00002555657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005043342,"about_ca_topic_score_gemma":0.000007546244,"domain_scores_codex":[0.998965,0.0003169603,0.0002145013,0.0002881403,0.00006233688,0.0001530339],"domain_scores_gemma":[0.9993946,0.0000134991,0.0001506021,0.0003507591,0.00005017443,0.0000403781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002610786,0.00007620325,0.001568745,0.00007825896,0.00008022094,4.03155e-7,0.0004834399,0.00001335644,0.9970934,0.00001563918,9.566123e-7,0.0003283469],"study_design_scores_gemma":[0.0004972497,0.0001897316,0.05644596,0.00001683303,0.00006752128,0.000005452678,0.0000432974,0.00001958926,0.9423424,0.0002581635,0.00001322178,0.0001006096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975863,0.001050461,0.0008416677,0.0000667811,0.00005944486,0.0002536433,0.00007397403,0.000007964414,0.00005977145],"genre_scores_gemma":[0.9997444,0.00005212766,0.0001286014,0.00001718045,0.00000933197,0.000007355114,0.00001280123,0.00001476198,0.00001342582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05487721,"threshold_uncertainty_score":0.4109262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00968304818687716,"score_gpt":0.1993787648625843,"score_spread":0.1896957166757071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}