{"id":"W2129105261","doi":"10.2174/15701638113109990001","title":"A Phosphoproteomics Approach to Identify Candidate Kinase Inhibitor Pathway Targets in Lymphoma-Like Primary Cell Lines","year":2013,"lang":"en","type":"article","venue":"Current Drug Discovery Technologies","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Phosphoproteomics; Kinase; Computational biology; Cancer research; Biology; Lymphoma; Cell culture; Cell biology; Chemistry; Protein kinase A; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001766772,0.0004749258,0.0005095559,0.00102733,0.0003423284,0.0004412588,0.0003447493,0.0002638049,0.001459331],"category_scores_gemma":[0.0002257876,0.0002358112,0.0004943945,0.0008250956,0.0001594535,0.0002062743,0.0002738091,0.0004628492,0.0005273721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004246961,"about_ca_system_score_gemma":0.0003445596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00132993,"about_ca_topic_score_gemma":0.002605047,"domain_scores_codex":[0.9998833,0.00001310878,0.00001038883,0.00004043802,0.00003491148,0.00001784962],"domain_scores_gemma":[0.9999322,0.0000177473,0.00001005848,0.00001072956,0.000018577,0.00001068835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008855094,0.00002850277,0.0004717402,0.00004356097,0.00001805683,0.0000497919,0.00001303912,0.000564912,0.9918097,0.0001595238,0.0000881455,0.006664437],"study_design_scores_gemma":[0.00004174453,0.0002073913,0.01114453,0.000004776078,0.00008304069,0.0005721134,0.00003264044,0.02625492,0.956566,0.0005751863,0.004504025,0.00001377669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.706241,0.002346967,0.2763951,0.0003247742,0.00004960668,0.0004934116,0.008481646,0.001784781,0.003882796],"genre_scores_gemma":[0.7537795,0.002286858,0.2317847,0.0001993342,0.00001770383,0.0006777696,0.007632285,0.0001353243,0.003486567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459331,"threshold_uncertainty_score":0.004881918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01514589028717323,"score_gpt":0.2684095524719469,"score_spread":0.2532636621847737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}