{"id":"W2129115386","doi":"10.1158/0008-5472.can-04-3272","title":"Effect of Conditional Knockout of the Type II <i>TGF-β</i> Receptor Gene in Mammary Epithelia on Mammary Gland Development and Polyomavirus Middle T Antigen Induced Tumor Formation and Metastasis","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":249,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada); McGill University","funders":"National Cancer Institute; Vanderbilt-Ingram Cancer Center; Vanderbilt University","keywords":"Carcinogenesis; Biology; Mammary tumor; Mammary gland; Cancer research; Transforming growth factor; Conditional gene knockout; Metastasis; Mouse mammary tumor virus; Internal medicine; Cancer; Endocrinology; Pathology; Breast cancer; Immunology; Medicine; Phenotype; Gene; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002569452,0.0005664604,0.0003940554,0.0004418197,0.0002122275,0.0004542693,0.000376758,0.0005627531,0.001808869],"category_scores_gemma":[0.0002033314,0.0003981859,0.0004387943,0.0001881534,0.0006622356,0.0003117456,0.0003781688,0.0009646041,0.00061402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004945351,"about_ca_system_score_gemma":0.0004442287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001292614,"about_ca_topic_score_gemma":0.001430394,"domain_scores_codex":[0.9995885,0.00007812215,0.00005849188,0.00008498027,0.00008377256,0.0001060715],"domain_scores_gemma":[0.9993699,0.0001025472,0.0002054912,0.00007283971,0.00002591934,0.0002232326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003490245,0.00005882723,0.0001176674,0.00001724473,0.000005554196,0.00007404076,0.00001252395,0.0000546836,0.9987831,0.0001467661,0.00002415649,0.0003565477],"study_design_scores_gemma":[0.00006876722,0.0006167601,0.003348559,0.000009578166,0.00003111615,0.0003307677,0.00005561302,0.0009842365,0.9927984,0.00006995561,0.001676688,0.000009443756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957284,0.0009027905,0.001230645,0.0001305168,0.00005470129,0.00003846669,0.0005682922,0.0001367374,0.001209411],"genre_scores_gemma":[0.9934263,0.000654367,0.001385472,0.00006823779,0.0000103431,0.00005025775,0.000534002,0.00008257183,0.003788547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001808869,"threshold_uncertainty_score":0.006051302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03813312648499063,"score_gpt":0.3346635005458449,"score_spread":0.2965303740608543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}