{"id":"W2129136620","doi":"10.1016/j.cell.2012.04.024","title":"Mutational Processes Molding the Genomes of 21 Breast Cancers","year":2012,"lang":"en","type":"article","venue":"Cell","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1999,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; National Research Council Canada; BC Cancer Agency; Norges Forskningsråd; Biotechnology and Biological Sciences Research Council; Fonds Wetenschappelijk Onderzoek; Vlaamse regering; European Commission; National Institute for Health and Care Research; King's College London; King's College Hospital NHS Foundation Trust; Wellcome Trust","keywords":"Biology; Genome; Breast cancer; Molding (decorative); Genetics; Computational biology; Evolutionary biology; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003089987,0.0001541045,0.0003223704,0.001231168,0.0003254182,0.0006316265,0.0001883551,0.0002506096,0.000394275],"category_scores_gemma":[0.001291939,0.0002730947,0.0003114191,0.001123641,0.0002781582,0.000253208,0.0003297007,0.0001739497,0.0001536172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005872099,"about_ca_system_score_gemma":0.000431648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001734857,"about_ca_topic_score_gemma":0.003189964,"domain_scores_codex":[0.9997341,0.00004808326,0.00002303084,0.00007954353,0.00007658065,0.00003864524],"domain_scores_gemma":[0.9995907,0.0001662417,0.0001234368,0.00004620585,0.00005230289,0.00002110477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008222848,0.00007916861,0.2044385,0.0004568025,0.0001200913,0.0008397893,0.0007369252,0.03609644,0.6729593,0.006977098,0.0003596278,0.07611407],"study_design_scores_gemma":[0.00005821464,0.000480264,0.5897304,0.00005011299,0.0002305892,0.003877447,0.0005214146,0.08800967,0.2837416,0.01121462,0.02198774,0.00009802594],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946062,0.0005170793,0.00351691,0.00002900396,0.000001761006,0.00001860636,0.0007373553,0.00004173253,0.0005312377],"genre_scores_gemma":[0.9836948,0.0007605772,0.01140924,0.00003780009,0.000004508948,0.0000545062,0.003450495,0.00002556753,0.0005625588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001734857,"threshold_uncertainty_score":0.00426054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007594422982755459,"score_gpt":0.225315348655071,"score_spread":0.2177209256723155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}