{"id":"W2129141528","doi":"10.1016/j.ccell.2015.02.003","title":"Self-Enforcing Feedback Activation between BCL6 and Pre-B Cell Receptor Signaling Defines a Distinct Subtype of Acute Lymphoblastic Leukemia","year":2015,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":142,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"National Cancer Institute; Cancer Research UK; Wellcome Trust; Howard Hughes Medical Institute","keywords":"breakpoint cluster region; Cancer research; Biology; BCL6; Tyrosine kinase; Signal transduction; Leukemia; Kinase; Receptor; Cell biology; Immunology; B cell; Genetics; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001780547,0.0001895205,0.0002841317,0.0005052641,0.0003831681,0.001418381,0.0005121222,0.0003323894,0.00237586],"category_scores_gemma":[0.000319491,0.0001679662,0.0002187374,0.0003795284,0.0003984766,0.0004006848,0.0005625715,0.000796111,0.0007413561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006017869,"about_ca_system_score_gemma":0.0003081582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00114891,"about_ca_topic_score_gemma":0.001572272,"domain_scores_codex":[0.9996914,0.00004212762,0.00002042113,0.00004976811,0.0000907556,0.0001055669],"domain_scores_gemma":[0.9997264,0.00003763854,0.00007112938,0.00006808976,0.00003585154,0.00006090566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008827869,0.0001842738,0.03045933,0.00004145572,0.00001774605,0.000519074,0.000261339,0.0002313701,0.9504926,0.005081702,0.0005035961,0.01132459],"study_design_scores_gemma":[0.0002634972,0.001523524,0.3408087,0.00003830191,0.0001160936,0.02606706,0.002497492,0.007313378,0.5825965,0.004186545,0.03453552,0.00005339687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960272,0.0004738382,0.0009694798,0.00008348763,0.00001187105,0.00001833471,0.0001986341,0.00006403196,0.002153025],"genre_scores_gemma":[0.997581,0.0002110461,0.000437246,0.00005868073,0.000009649765,0.00001016437,0.0003982442,0.00001678653,0.001277051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00237586,"threshold_uncertainty_score":0.007948101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02639569403894095,"score_gpt":0.2885069859949592,"score_spread":0.2621112919560182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}