{"id":"W2129168139","doi":"10.3390/molecules15031590","title":"Preparation of 16β-Estradiol Derivative Libraries as Bisubstrate Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 Using the Multidetachable Sulfamate Linker","year":2010,"lang":"en","type":"article","venue":"Molecules","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Linker; Estrone; Steroid; Hydroxysteroid dehydrogenase; Cofactor; Stereochemistry; Dehydrogenase; Amino acid; Cleavage (geology); Combinatorial chemistry; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001379925,0.0001748146,0.0001822269,0.00004577736,0.0000873151,0.00002313796,0.0001746583,0.0002376337,0.000007992742],"category_scores_gemma":[0.00009234963,0.0001277123,0.00010263,0.0001558955,0.0002643537,0.0000126019,0.00007260237,0.0001698184,0.000004322002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003860646,"about_ca_system_score_gemma":0.0001298444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006450677,"about_ca_topic_score_gemma":0.00001479201,"domain_scores_codex":[0.9990519,0.00009235223,0.0003051177,0.0002328675,0.0001290975,0.0001886696],"domain_scores_gemma":[0.9992376,0.00002469339,0.0002323986,0.0003430892,0.0001046584,0.00005753479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001781005,0.00005673626,0.0009482073,0.00003114936,0.0001083986,0.000004768478,0.0002302829,0.0009331254,0.9970903,0.0002802143,0.00005078954,0.00008796503],"study_design_scores_gemma":[0.0002983201,0.0003633334,0.0003018098,0.00002861529,0.00004623998,0.00003173931,0.00007828169,0.001561867,0.9967865,0.0001040475,0.0002644433,0.0001348166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979107,0.001038807,0.0001727042,0.00002624775,0.0001699881,0.0002925714,0.00001197635,0.00001202797,0.000365021],"genre_scores_gemma":[0.9983639,0.00005947941,0.001300166,0.00003038342,0.00007275357,0.000008419005,0.00006187024,0.00002686448,0.00007612285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001127462,"threshold_uncertainty_score":0.5207955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008663787931893947,"score_gpt":0.2733236469412071,"score_spread":0.2646598590093132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}