{"id":"W2129168139","doi":"10.3390/molecules15031590","title":"Preparation of 16β-Estradiol Derivative Libraries as Bisubstrate Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 Using the Multidetachable Sulfamate Linker","year":2010,"lang":"en","type":"article","venue":"Molecules","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Linker; Estrone; Steroid; Hydroxysteroid dehydrogenase; Cofactor; Stereochemistry; Dehydrogenase; Amino acid; Cleavage (geology); Combinatorial chemistry; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001788502,0.0006361327,0.000527825,0.0004373711,0.0001161653,0.0003246138,0.0002839795,0.0002270774,0.001569832],"category_scores_gemma":[0.0001901658,0.0002438398,0.0002982617,0.0005408662,0.0001258074,0.000210714,0.0002743694,0.0003922639,0.0008556234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001797364,"about_ca_system_score_gemma":0.0002037057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002070829,"about_ca_topic_score_gemma":0.0005224046,"domain_scores_codex":[0.9998105,0.00002875293,0.00001759094,0.00003663995,0.00006730042,0.00003911697],"domain_scores_gemma":[0.9998851,0.00001991884,0.00002491204,0.00001671406,0.00002318709,0.00003009506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001002668,0.00004926962,0.0001094508,0.00003444356,0.00001092616,0.00006143129,0.00001681212,0.000310605,0.9941688,0.00008204069,0.00005180849,0.005004121],"study_design_scores_gemma":[0.00002602967,0.0006496614,0.0005351969,0.00000377414,0.00003076132,0.0001753773,0.000009949483,0.0005077705,0.9942613,0.00002904313,0.003762877,0.000008197649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789642,0.001794253,0.01363333,0.0000619022,0.00003656886,0.0002776051,0.001212509,0.000272549,0.003747183],"genre_scores_gemma":[0.9505467,0.003697699,0.02701676,0.0001429687,0.00003080116,0.0003038525,0.005040947,0.0001326077,0.01308766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001569832,"threshold_uncertainty_score":0.005251646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008663787931893947,"score_gpt":0.2733236469412071,"score_spread":0.2646598590093132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}