{"id":"W2129168442","doi":"10.2337/db08-1371","title":"Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells","year":2009,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; University of Alberta","funders":"University of California, San Diego; University of Oxford","keywords":"Exocytosis; Cell biology; Biology; Tensin; Beta cell; Total internal reflection fluorescence microscope; Secretion; Insulin; PI3K/AKT/mTOR pathway; Endocrinology; Islet; PTEN; Signal transduction; Biochemistry; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001656958,0.0001746854,0.0003417021,0.0001864702,0.00006573978,0.00003004251,0.00003647293,0.00009185918,0.0000890652],"category_scores_gemma":[0.00005926962,0.0001492295,0.00003221554,0.0001507119,0.00004993278,0.00005535674,0.00002097542,0.0001392065,0.00003146562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004852354,"about_ca_system_score_gemma":0.00001740634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002598569,"about_ca_topic_score_gemma":0.00000256456,"domain_scores_codex":[0.998972,0.00003713288,0.00023848,0.0003200494,0.0001709497,0.0002613718],"domain_scores_gemma":[0.9994613,0.00008973363,0.00004888998,0.0002020491,0.00002978186,0.0001682658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001784933,0.001234283,0.5908133,0.0002040788,0.00009014759,0.00003768532,0.001156342,0.000003070729,0.333061,0.0007814204,0.002136587,0.07030355],"study_design_scores_gemma":[0.004335459,0.001686297,0.6339536,0.0002793326,0.00006813092,0.000002012778,0.0001167172,0.0001258364,0.3562017,0.0009700364,0.002034223,0.0002266819],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932919,0.001649517,7.541975e-7,0.0008882022,0.00005802497,0.0004642149,0.000009040638,0.00004499283,0.003593335],"genre_scores_gemma":[0.99462,0.0002024769,0.0001324359,0.004518456,0.00005421758,0.00004146135,0.00001395803,0.00001157142,0.0004054597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07007688,"threshold_uncertainty_score":0.6085401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03654953704344164,"score_gpt":0.281892434996009,"score_spread":0.2453428979525674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}